2. Gene
  3. Lats1 - large tumor suppressor Gene

Lats1 - large tumor suppressor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 16798 | Gene type: protein coding

About Lats1

Summary

Predicted to enable several functions, including ATP binding activity; Estrogen receptor binding activity; and magnesium ion binding activity. Involved in hormone-mediated signaling pathway; negative regulation of protein localization to nucleus; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Predicted to be located in cytoplasm and Cytoskeleton. Predicted to be active in spindle pole. Is expressed in acoustic ganglion; early conceptus; embryo; endolymphatic appendage; and otocyst. Orthologous to human LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Lats1 Products(1)

mRNA Protein Name
NM_010690.1 NP_034820.1 serine/threonine-protein kinase LATS1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21145499 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within hippo signaling IGI
IGI: Inferred from genetic interaction
18369314 MGI
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
9988269 MGI
acts upstream of or within inner cell mass cell fate commitment IGI
IGI: Inferred from genetic interaction
23824537 MGI
acts upstream of or within inner cell mass cellular morphogenesis IGI
IGI: Inferred from genetic interaction
23824537 MGI
acts upstream of or within keratinocyte differentiation IGI
IGI: Inferred from genetic interaction
18369314 MGI
involved in negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
21145499 MGI
acts upstream of or within protein localization IGI
IGI: Inferred from genetic interaction
19289085 MGI
involved in regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21145499 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase LATS1

WARTS protein kinase

large tumor suppressor homolog 1

large tumor supressor, homolog 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-164401 QBS10072S / Phase 2
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138489 TRULI Modulator 99.98% Unkown
HY-108540 BCH Inducer 99.13% Unkown
HY-147082 GA-017 Activator 98.95% Unkown
HY-W011391 GPNA hydrochloride 99.91% Unkown
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-W087830 L-p-Boronophenylalanine 99.84% Unkown
HY-120139 KMH-233 Inhibitor 99.75% Unkown
HY-120139A (R)-KMH-233 Control / Unkown
HY-RS07538 LATS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown
HY-RS17343 Lats1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23797 Lats1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lats1 NCBI NCBI:9113