2. Gene
  3. Dsg4 - desmoglein 4 Gene

Dsg4 - desmoglein 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as lah; CDHF13

Gene ID: 16769 | Gene type: protein coding

About Dsg4

Summary

This gene encodes a member of the Cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the Cytoskeleton, cell sorting and cell signaling. This gene is expressed in the suprabasal epidermis and hair follicle. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Certain mutations in this gene are responsible for the lanceolate hair phenotype in mice. This gene is located in a cluster of desmosomal Cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016]

Dsg4 Products(1)

mRNA Protein Name
NM_181564.3 NP_853543.1 desmoglein-4 preproprotein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
18692037 MGI
acts upstream of or within anagen IMP
IMP: Inferred from mutant phenotype
12705872 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
12705872 MGI
acts upstream of or within hair follicle development IDA
IDA: Inferred from direct assay
18692037 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
12705872 MGI
Cellular Component GO Annotation Evidence Reference Source
located in desmosome IMP
IMP: Inferred from mutant phenotype
12705872 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desmoglein-4

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04024 DSG4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19127 Dsg4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25617 Dsg4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dsg4 NCBI NCBI:147409