DEFA4 - defensin alpha 4 Gene

Homo sapiens

Also known as HP4; DEF4; HP-4; HNP-4

Gene ID: 1669 | Gene type: protein coding

About DEFA4

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:6,935,820-6,938,306 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 165 orthologues and 5 paralogues. Restricted expression toward bone marrow (RPKM 1355.2).

Summary

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from Other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]

DEFA4 Products(1)

mRNA	Protein	Name
NM_001925.3	NP_001916.1	defensin alpha 4 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17088326	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell chemotaxis	IDA IDA: Inferred from direct assay	17088326	GOA
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	2500436	GOA
involved in antifungal humoral response	IDA IDA: Inferred from direct assay	2500436	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	2500436	GOA
involved in antimicrobial humoral response	IDA IDA: Inferred from direct assay	2500436	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	2500436	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	2500436	GOA
involved in defense response to fungus	IDA IDA: Inferred from direct assay	2500436	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	2500436	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	15616305	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in azurophil granule	IDA IDA: Inferred from direct assay	2500436	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEFA4 Protein Structure

Defensin_propep

Defensin_1

0
97 a.a.

Protein Preferred Names

Protein Names

defensin alpha 4

corticostatin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03675	DEFA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DEFA4	RGD	RGD:727857

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