2. Gene
  3. Krt1 - keratin 1 Gene

Krt1 - keratin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Krt86; Krt2-1; Krt-2.1

Gene ID: 16678 | Gene type: protein coding

About Krt1

Summary

Predicted to enable carbohydrate binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Acts upstream of or within establishment of skin barrier and negative regulation of inflammatory response. Located in keratin filament. Is expressed in autopod; nose; skin; and tongue. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis; epidermolytic palmoplantar keratoderma; and nonepidermolytic palmoplantar keratoderma. Orthologous to human KRT1 (keratin 1). [provided by Alliance of Genome Resources, Apr 2022]

Krt1 Products(1)

mRNA Protein Name
NM_008473.2 NP_032499.2 keratin, type II cytoskeletal 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11408584 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
23132931 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
23132931 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
23132931 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in keratin filament IDA
IDA: Inferred from direct assay
2404337 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 1

67 kDa cytokeratin

CK-1

K1

cytokeratin-1

keratin 86

keratin complex 2, basic, gene 1

type-II keratin Kb1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10789 P160 peptide Inhibitor / Unkown
HY-P10790 Breast cancer targeting peptide 18–4 Inhibitor / Unkown
HY-RS07433 KRT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19346 Krt1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25837 Krt1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt1 NCBI NCBI:3848
Canis familiaris Krt1 NCBI NCBI:444857