Mafb - v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) Gene

Mus musculus

Also known as kr; Krml; Krml1; Kreisler

Gene ID: 16658 | Gene type: protein coding

About Mafb

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in abducens nerve formation; negative regulation of osteoclast differentiation; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and respiratory gaseous exchange by respiratory system. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Used to study Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Human ortholog(s) of this gene implicated in Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Orthologous to human MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Apr 2022]

Mafb Products(1)

mRNA	Protein	Name
NM_010658.3	NP_034788.1	transcription factor MafB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12701106	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	12701106	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	12701106	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12798298	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11823429	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	19164599	MGI
involved in abducens nerve formation	IMP IMP: Inferred from mutant phenotype	27181683	MGI
acts upstream of or within brain segmentation	IMP IMP: Inferred from mutant phenotype	7925021	MGI
involved in cornified envelope assembly	IMP IMP: Inferred from mutant phenotype	27208706	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	27208706	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	16325169	MGI
involved in keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	27208706	MGI
involved in negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	19440205	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11823429	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12798298	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12701106	MGI
involved in protein processing	IMP IMP: Inferred from mutant phenotype	27208706	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12701106	MGI
acts upstream of or within respiratory gaseous exchange by respiratory system	IMP IMP: Inferred from mutant phenotype	14513037	MGI
acts upstream of or within rhombomere 5 development	IMP IMP: Inferred from mutant phenotype	7925021	MGI
acts upstream of or within rhombomere 6 development	IMP IMP: Inferred from mutant phenotype	7925021	MGI
acts upstream of or within segment specification	IMP IMP: Inferred from mutant phenotype	12701106	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	19164599	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12917329	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12798298	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor MafB

Kreisler (maf-related) leucine zipper protein	V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
maf-B	segmentation protein Kr
transcription factor Maf-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07959	MAFB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19144	Mafb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25635	Mafb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mafb	NCBI	NCBI:9935

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