Kpna2 - karyopherin (importin) alpha 2 Gene

Mus musculus

Also known as Rch1; IPOA1; PTAC58; 2410044B12Rik

Gene ID: 16647 | Gene type: protein coding

About Kpna2

Summary

Enables DNA-binding transcription factor binding activity and nuclear import signal receptor activity. Acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of viral life cycle; and protein import into nucleus. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Kpna2 Products(1)

mRNA	Protein	Name
NM_010655.3	NP_034785.1	importin subunit alpha-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12695505	MGI
enables nuclear import signal receptor activity	IDA IDA: Inferred from direct assay	15689618	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10764582	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin	IMP IMP: Inferred from mutant phenotype	28189564	MGI
acts upstream of or within positive regulation of viral life cycle	IMP IMP: Inferred from mutant phenotype	28189564	MGI
involved in postsynapse to nucleus signaling pathway	IDA IDA: Inferred from direct assay	15603742	MGI
involved in postsynapse to nucleus signaling pathway	IMP IMP: Inferred from mutant phenotype	15603742	MGI
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	15689618	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	27430620	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15603742	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15603742	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	15603742	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	15603742	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

importin subunit alpha-1

RAG cohort protein 1	SRP1-alpha
importin alpha 1	importin alpha P1
importin subunit alpha-2	karyopherin subunit alpha-2
m-importin-alpha-P1	pendulin
pore targeting complex 58 kDa subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07416	KPNA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17914	Kpna2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24383	Kpna2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kpna2	NCBI	NCBI:3838

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