Klf1 - Kruppel-like factor 1 (erythroid) Gene

Mus musculus

Also known as Nan; Eklf

Gene ID: 16596 | Gene type: protein coding

About Klf1

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in erythrocyte differentiation; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including chromatin remodeling; hemopoiesis; and liver development. Predicted to be located in chromatin and nucleoplasm. Is expressed in several structures, including extraembryonic component; hemolymphoid system; olfactory placode; testis; and urethra. Used to study beta thalassemia and hereditary spherocytosis. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (Kruppel like factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Klf1 Products(1)

mRNA	Protein	Name
NM_010635.3	NP_034765.3	Krueppel-like factor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	22835905	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17442339	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	17442339	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	22835905	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19251649	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17442339	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19251649	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	19251649	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chromatin remodeling	IDA IDA: Inferred from direct assay	15489291	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	7753194	MGI
acts upstream of or within erythrocyte development	IMP IMP: Inferred from mutant phenotype	7753194	MGI
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	22835905	MGI
acts upstream of or within erythrocyte maturation	IMP IMP: Inferred from mutant phenotype	7753195	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	7753194	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	7753194	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19251649	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22835905	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19251649	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17442339	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Krueppel-like factor 1

erythroid krueppel-like transcription factor	erythroid transcription factor
neonatal anemia

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07330	KLF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18769	Klf1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25257	Klf1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Klf1	NCBI	NCBI:10661

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