2. Gene
  3. Kif5b - kinesin family member 5B Gene

Kif5b - kinesin family member 5B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Khc; Khcs; Kns1; Ukhc

Gene ID: 16573 | Gene type: protein coding

About Kif5b

Summary

Predicted to enable several functions, including ATP hydrolysis activity; JUN kinase binding activity; and microtubule lateral binding activity. Involved in positive regulation of GABAergic synaptic transmission and stress granule disassembly. Acts upstream of or within cellular response to interferon-gamma; cytoplasm organization; and plus-end-directed vesicle transport along microtubule. Located in ciliary rootlet; neuron projection; and phagocytic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KIF5B (Kinesin family member 5B). [provided by Alliance of Genome Resources, Apr 2022]

Kif5b Products(1)

mRNA Protein Name
NM_008448.3 NP_032474.2 kinesin-1 heavy chain
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9624122 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
29276473 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
acts upstream of or within cytoplasm organization IMP
IMP: Inferred from mutant phenotype
9657148 MGI
acts upstream of or within mitochondrion transport along microtubule IMP
IMP: Inferred from mutant phenotype
34048705 MGI
acts upstream of or within mitocytosis IMP
IMP: Inferred from mutant phenotype
34048705 MGI
acts upstream of or within plus-end-directed vesicle transport along microtubule IMP
IMP: Inferred from mutant phenotype
17360972 MGI
involved in positive regulation of synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
20152113 MGI
involved in regulation of modification of synapse structure, modulating synaptic transmission IDA
IDA: Inferred from direct assay
31961321 MGI
involved in regulation of modification of synapse structure, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
31961321 MGI
involved in stress granule disassembly IMP
IMP: Inferred from mutant phenotype
19825938 MGI
acts upstream of or within vesicle transport along microtubule IGI
IGI: Inferred from genetic interaction
17360972 MGI
Cellular Component GO Annotation Evidence Reference Source
located in ciliary rootlet IDA
IDA: Inferred from direct assay
16018997 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16018997 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
17360972 MGI
located in membrane-bounded organelle IDA
IDA: Inferred from direct assay
12805290 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
34048705 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
16301330 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
31961321 MGI
is active in postsynaptic cytosol IEP
IEP: Inferred from expression pattern
31961321 MGI
is active in postsynaptic cytosol IMP
IMP: Inferred from mutant phenotype
31961321 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin-1 heavy chain

conventional kinesin heavy chain

kinesin heavy chain member 5B, ubiquitous

ubiquitous kinesin heavy chain

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-133551 WF-47-JS03 Inhibitor 99.63% Unkown
HY-146710 RET-IN-16 Inhibitor / Unkown
HY-170852 QZ2135 Degrader / Unkown
HY-170855A YW-N-7 TFA Degrader / Unkown
HY-RS07290 KIF5B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18287 Kif5b Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24765 Kif5b Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kif5b NCBI NCBI:3799