Kcnq2 - potassium voltage-gated channel, subfamily Q, member 2 Gene

Mus musculus

Also known as KQT2; HNSPC; Nmf134

Gene ID: 16536 | Gene type: protein coding

About Kcnq2

Summary

Enables Calmodulin binding activity and voltage-gated ion channel activity. Acts upstream of or within membrane hyperpolarization and transmission of nerve impulse. Located in cell surface; main axon; and plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including brain; gut; immune system; reproductive system; and white fat. Used to study benign neonatal seizures and developmental and epileptic encephalopathy 7. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq2 Products(7)

mRNA	Protein	Name
NM_001003824.2	NP_001003824.1	potassium voltage-gated channel subfamily KQT member 2 isoform 2
NM_001003825.3	NP_001003825.1	potassium voltage-gated channel subfamily KQT member 2 isoform 3
NM_001006668.2	NP_001006669.1	potassium voltage-gated channel subfamily KQT member 2 isoform 4
NM_001006669.2	NP_001006670.1	potassium voltage-gated channel subfamily KQT member 2 isoform 5
NM_001006674.2	NP_001006675.1	potassium voltage-gated channel subfamily KQT member 2 isoform 6
NM_001302888.1	NP_001289817.1	potassium voltage-gated channel subfamily KQT member 2 isoform 13
NM_010611.3	NP_034741.2	potassium voltage-gated channel subfamily KQT member 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin binding	IMP IMP: Inferred from mutant phenotype	24333508	MGI
enables calmodulin binding	IPI IPI: Inferred from physical interaction	12223552	MGI
enables potassium channel activity	IGI IGI: Inferred from genetic interaction	23716673	MGI
enables potassium channel activity	IMP IMP: Inferred from mutant phenotype	14762142	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14762142	MGI
enables voltage-gated monoatomic ion channel activity	IGI IGI: Inferred from genetic interaction	12223552	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within action potential	IDA IDA: Inferred from direct assay	14762142	MGI
acts upstream of or within action potential	IMP IMP: Inferred from mutant phenotype	14762142	MGI
acts upstream of or within action potential initiation	IDA IDA: Inferred from direct assay	26312501	MGI
acts upstream of or within action potential initiation	IGI IGI: Inferred from genetic interaction	23716673	MGI
acts upstream of or within action potential initiation	IMP IMP: Inferred from mutant phenotype	24719109	MGI
acts upstream of or within apoptosome assembly	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within behavior	IMP IMP: Inferred from mutant phenotype	15608631	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	30382937	MGI
acts upstream of or within cellular response to calcium ion	IDA IDA: Inferred from direct assay	23259949	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	23259949	MGI
acts upstream of or within cognition	IMP IMP: Inferred from mutant phenotype	15608631	MGI
acts upstream of or within dentate gyrus development	IGI IGI: Inferred from genetic interaction	16464983	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	21156207	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	24719109	MGI
acts upstream of or within endocytosis	IMP IMP: Inferred from mutant phenotype	21466805	MGI
acts upstream of or within establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	24719109	MGI
acts upstream of or within excitatory chemical synaptic transmission	IDA IDA: Inferred from direct assay	14762142	MGI
acts upstream of or within excitatory chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	30382937	MGI
acts upstream of or within exocytosis	IMP IMP: Inferred from mutant phenotype	21466805	MGI
acts upstream of or within exploration behavior	IMP IMP: Inferred from mutant phenotype	31283873	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	24333508	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	18483067	MGI
acts upstream of or within grooming behavior	IMP IMP: Inferred from mutant phenotype	31283873	MGI
acts upstream of or within hippocampal pyramidal neuron differentiation	IMP IMP: Inferred from mutant phenotype	15608631	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	15608631	MGI
acts upstream of or within inhibitory chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	30382937	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	32239694	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	15608631	MGI
acts upstream of or within mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	18483067	MGI
acts upstream of or within motor behavior	IMP IMP: Inferred from mutant phenotype	19453707	MGI
acts upstream of or within nerve development	IGI IGI: Inferred from genetic interaction	16464983	MGI
acts upstream of or within nerve development	IMP IMP: Inferred from mutant phenotype	18483067	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	21466805	MGI
acts upstream of or within neuron remodeling	IGI IGI: Inferred from genetic interaction	30382937	MGI
acts upstream of or within neuronal action potential	IMP IMP: Inferred from mutant phenotype	24719109	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	21466805	MGI
acts upstream of or within protein transport	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within psychomotor behavior	IMP IMP: Inferred from mutant phenotype	19453707	MGI
acts upstream of or within regulation of action potential firing threshold	IGI IGI: Inferred from genetic interaction	23716673	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	15608631	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18483067	MGI
acts upstream of or within response to auditory stimulus	IDA IDA: Inferred from direct assay	26312501	MGI
acts upstream of or within response to auditory stimulus	IGI IGI: Inferred from genetic interaction	23716673	MGI
acts upstream of or within response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	24687876	MGI
acts upstream of or within response to organic cyclic compound	IDA IDA: Inferred from direct assay	20885443	MGI
acts upstream of or within response to temperature stimulus	IMP IMP: Inferred from mutant phenotype	24687876	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	14762142	MGI
acts upstream of or within sensory perception of sound	IGI IGI: Inferred from genetic interaction	23716673	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	31283873	MGI
acts upstream of or within sodium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	16464983	MGI
acts upstream of or within substantia propria of cornea development	IMP IMP: Inferred from mutant phenotype	19453707	MGI
acts upstream of or within transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	10854243	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in axon initial segment	IDA IDA: Inferred from direct assay	14762142	MGI
located in axon initial segment	IDA IDA: Inferred from direct assay	16525039	MGI
located in cell surface	IDA IDA: Inferred from direct assay	12223552	MGI
is active in node of Ranvier	IDA IDA: Inferred from direct assay	14762142	MGI
located in node of Ranvier	IDA IDA: Inferred from direct assay	16525039	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16525039	MGI
part of voltage-gated potassium channel complex	IGI IGI: Inferred from genetic interaction	12223552	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily KQT member 2

KQT-like 2	potassium channel subunit alpha KvLQT2
voltage-gated potassium channel subunit Kv7.2

Related Agents

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108577	XE991 dihydrochloride	Inhibitor	99.63%	Unkown
HY-122114	ICA-27243	Activator	99.27%	Unkown
HY-101396	ICA-069673	Activator	99.20%	Unkown
HY-113616A	VU0364572 TFA	Agonist	99.27%	Unkown
HY-145016	HN37	Activator	99.53%	Unkown
HY-157485	Ebio1	Activator	99.99%	Unkown
HY-108587	ICA 110381	Modulator	99.85%	Unkown
HY-18063	ML252	Inhibitor	99.9%	Unkown
HY-108577A	XE991	Inhibitor	99.62%	Unkown
HY-123264	RL648_81	Inhibitor	99.20%	Unkown
HY-113616	VU0364572	Agonist	/	Unkown
HY-130070	QO-40	Activator	98.77%	Unkown
HY-168214	Kv7.2/Kv7.3 agonist 1	Inhibitor	/	Unkown
HY-172140	Ebio3	Inhibitor	/	Unkown
HY-172141	Ebio2	Activator	/	Unkown
HY-RS07174	KCNQ2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-115823	ztz240		/	Unkown
HY-18063A	ML252 hydrochloride	Inhibitor	/	Unkown
HY-RS17110	Kcnq2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23555	Kcnq2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnq2	NCBI	NCBI:3785

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