Kcnk1 - potassium channel, subfamily K, member 1 Gene

Mus musculus

Also known as TWIK-1

Gene ID: 16525 | Gene type: protein coding

About Kcnk1

Summary

Enables inward rectifier Potassium Channel activity. Involved in potassium ion transmembrane transport. Located in endosome. Is integral component of plasma membrane. Part of inward rectifier Potassium Channel complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnk1 Products(1)

mRNA	Protein	Name
NM_008430.2	NP_032456.2	potassium channel subfamily K member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	24496152	MGI
enables inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	9013852	MGI
enables ligand-gated channel activity	IDA IDA: Inferred from direct assay	24496152	MGI
enables potassium channel activity	IDA IDA: Inferred from direct assay	15540117	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15540117	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	24496152	MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	25406588	MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	25406588	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	24496152	MGI
involved in glutamate secretion	IDA IDA: Inferred from direct assay	24496152	MGI
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	9013852	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	15540117	MGI
part of inward rectifier potassium channel complex	IDA IDA: Inferred from direct assay	9013852	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	24496152	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	9013852	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium channel subfamily K member 1

inward rectifying potassium channel protein TWIK-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07152	KCNK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21612	Kcnk1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28130	Kcnk1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnk1	NCBI	NCBI:3775

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