Kcnj8 - potassium inwardly-rectifying channel, subfamily J, member 8 Gene

Mus musculus

Also known as sltr; gnite; slmbr; Kir6.1; uKATP-1

Gene ID: 16523 | Gene type: protein coding

About Kcnj8

Summary

Predicted to enable several functions, including ATP binding activity; sulfonylurea receptor binding activity; and voltage-gated Potassium Channel activity. Acts upstream of or within several processes, including defense response to virus; response to exogenous dsRNA; and response to lipopolysaccharide. Located in myofibril. Is expressed in genitourinary system and heart. Used to study coronary artery disease and hypertrichotic osteochondrodysplasia Cantu type. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj8 Products(6)

mRNA	Protein	Name
NM_001330363.1	NP_001317292.1	ATP-sensitive inward rectifier potassium channel 8 isoform 1
NM_001330366.1	NP_001317295.1	ATP-sensitive inward rectifier potassium channel 8 isoform 2
NM_008428.5	NP_032454.1	ATP-sensitive inward rectifier potassium channel 8 isoform 1
NM_001330363.1	NP_001317292.1	ATP-sensitive inward rectifier potassium channel 8 isoform 1
NM_001330366.1	NP_001317295.1	ATP-sensitive inward rectifier potassium channel 8 isoform 2
NM_008428.5	NP_032454.1	ATP-sensitive inward rectifier potassium channel 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18001767	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within CAMKK-AMPK signaling cascade	IMP IMP: Inferred from mutant phenotype	24498880	MGI
acts upstream of or within NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	28928055	MGI
acts upstream of or within NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	28928055	MGI
acts upstream of or within action potential	IGI IGI: Inferred from genetic interaction	16501027	MGI
acts upstream of or within action potential	IMP IMP: Inferred from mutant phenotype	21984445	MGI
acts upstream of or within adaptive immune response	IMP IMP: Inferred from mutant phenotype	17077304	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	24498880	MGI
acts upstream of or within atrioventricular node cell differentiation	IMP IMP: Inferred from mutant phenotype	29666184	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	30089727	MGI
acts upstream of or within calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	28893911	MGI
acts upstream of or within cardiac pacemaker cell differentiation	IMP IMP: Inferred from mutant phenotype	29666184	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	28928055	MGI
acts upstream of or within circulatory system development	IMP IMP: Inferred from mutant phenotype	30089727	MGI
acts upstream of or within coronary vasculature development	IGI IGI: Inferred from genetic interaction	31821173	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	11984590	MGI
acts upstream of or within cytokine production	IGI IGI: Inferred from genetic interaction	19166858	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	18026101	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	16501027	MGI
acts upstream of or within endothelin production	IMP IMP: Inferred from mutant phenotype	17341678	MGI
acts upstream of or within establishment of cell polarity	IDA IDA: Inferred from direct assay	29540778	MGI
acts upstream of or within establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	29540778	MGI
acts upstream of or within fat cell differentiation	IMP IMP: Inferred from mutant phenotype	26828268	MGI
acts upstream of or within fatty acid transport	IMP IMP: Inferred from mutant phenotype	26828268	MGI
acts upstream of or within fibroblast proliferation	IGI IGI: Inferred from genetic interaction	19166858	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	26828268	MGI
acts upstream of or within glutamate secretion, neurotransmission	IGI IGI: Inferred from genetic interaction	17883401	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	18026101	MGI
acts upstream of or within heart morphogenesis	IGI IGI: Inferred from genetic interaction	31821173	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	30089727	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	29540778	MGI
acts upstream of or within microglial cell activation	IMP IMP: Inferred from mutant phenotype	29540778	MGI
acts upstream of or within nervous system process	IMP IMP: Inferred from mutant phenotype	30315808	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	17883401	MGI
acts upstream of or within p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	29540778	MGI
acts upstream of or within phloem or xylem histogenesis	IMP IMP: Inferred from mutant phenotype	24914196	MGI
acts upstream of or within potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	28928055	MGI
acts upstream of or within protein secretion	IMP IMP: Inferred from mutant phenotype	26828268	MGI
acts upstream of or within reactive gliosis	IMP IMP: Inferred from mutant phenotype	30315808	MGI
acts upstream of or within regulation of blood pressure	IGI IGI: Inferred from genetic interaction	31821173	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	24914196	MGI
acts upstream of or within regulation of cation channel activity	IGI IGI: Inferred from genetic interaction	31821173	MGI
acts upstream of or within regulation of heart rate	IMP IMP: Inferred from mutant phenotype	29666184	MGI
acts upstream of or within response to ATP	IMP IMP: Inferred from mutant phenotype	21984445	MGI
acts upstream of or within response to cytokine	IMP IMP: Inferred from mutant phenotype	17077304	MGI
acts upstream of or within response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	30315808	MGI
acts upstream of or within response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	18026101	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	28893911	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	28928055	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	21984445	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17077304	MGI
acts upstream of or within response to resveratrol	IMP IMP: Inferred from mutant phenotype	24498880	MGI
acts upstream of or within response to stress	IGI IGI: Inferred from genetic interaction	16501027	MGI
acts upstream of or within response to xenobiotic stimulus	IGI IGI: Inferred from genetic interaction	31821173	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	11984590	MGI
acts upstream of or within synaptic assembly at neuromuscular junction	IMP IMP: Inferred from mutant phenotype	26142302	MGI
acts upstream of or within transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	26142302	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	11984590	MGI
acts upstream of or within vasodilation	IMP IMP: Inferred from mutant phenotype	11984590	MGI
acts upstream of or within ventricular cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	16501027	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in myofibril	IDA IDA: Inferred from direct assay	16085792	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	17883401	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17883401	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-sensitive inward rectifier potassium channel 8

inward rectifier K(+) channel Kir6.1

inwardly rectifier K(+) channel Kir6.1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07150	KCNJ8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22588	Kcnj8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnj8	NCBI	NCBI:3764

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