Kcnd2 - potassium voltage-gated channel, Shal-related family, member 2 Gene

Mus musculus

Also known as Kv4.2

Gene ID: 16508 | Gene type: protein coding

About Kcnd2

Summary

Enables A-type (transient outward) Potassium Channel activity and voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including locomotor rhythm; neuronal action potential; and potassium ion transmembrane transport. Acts upstream of or within action potential. Located in several cellular components, including GABA-ergic synapse; dendritic spine; and postsynaptic membrane. Is integral component of postsynaptic membrane. Part of voltage-gated Potassium Channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in several structures, including heart; hindlimb digit; metanephros; nervous system; and sensory organ. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnd2 Products(1)

mRNA	Protein	Name
NM_019697.4	NP_062671.1	potassium voltage-gated channel subfamily D member 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables A-type (transient outward) potassium channel activity	IDA IDA: Inferred from direct assay	9734479	MGI
enables A-type (transient outward) potassium channel activity	IMP IMP: Inferred from mutant phenotype	18045912	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15662035	MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	17582333	MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	17582333	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in locomotor rhythm	IMP IMP: Inferred from mutant phenotype	22815518	MGI
acts upstream of or within neuronal action potential	IMP IMP: Inferred from mutant phenotype	20573902	MGI
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	22815518	MGI
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	9734479	MGI
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	18045912	MGI
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	18045912	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	17122053	MGI
located in dendrite	IDA IDA: Inferred from direct assay	11040264	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	21943606	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17122053	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17582333	MGI
located in membrane	IDA IDA: Inferred from direct assay	18603586	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	11040264	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9734479	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	17122053	MGI
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	17122053	MGI
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	19713751	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily D member 2

voltage-gated potassium channel subunit Kv4.2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07113	KCND2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21609	Kcnd2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnd2	NCBI	NCBI:3751

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