2. Gene
  3. Itm2b - integral membrane protein 2B Gene

Itm2b - integral membrane protein 2B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Bri; Bri2; E25BMM; imBRI2; Bricd2b; D14Sel6

Gene ID: 16432 | Gene type: protein coding

About Itm2b

Summary

Enables ATP binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in Golgi-associated vesicle membrane and extracellular space. Predicted to be integral component of organelle membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in central nervous system; pancreas epithelium; and retina. Used to study cerebral amyloid angiopathy. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Apr 2022]

Itm2b Products(1)

mRNA Protein Name
NM_008410.3 NP_032436.1 integral membrane protein 2B precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
10679242 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20945367 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integral membrane protein 2B

immature BRI2

integral membrane protein 2B (E25B protein)

transmembrane protein BRI

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06984 ITM2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21603 Itm2b Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itm2b NCBI NCBI:9445