2. Gene
  3. Itih4 - inter alpha-trypsin inhibitor, heavy chain 4 Gene

Itih4 - inter alpha-trypsin inhibitor, heavy chain 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Itih-4; PK-120; ITI-HC4

Gene ID: 16427 | Gene type: protein coding

About Itih4

Summary

This gene encodes a member of the inter-alpha trypsin inhibitor (IaI) family of plasma serine Protease Inhibitors with diverse functions as anti-apoptotic and matrix stabilizing molecules during development. This gene is predominantly expressed in the liver and the encoded protein was found to be a plasma kallikrein-sensitive glycoprotein. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

Itih4 Products(8)

mRNA Protein Name
NM_001159299.2 NP_001152771.1 inter alpha-trypsin inhibitor, heavy chain 4 isoform 2 precursor
NM_001289632.1 NP_001276561.1 inter alpha-trypsin inhibitor, heavy chain 4 isoform 3 precursor
NM_001289633.1 NP_001276562.1 inter alpha-trypsin inhibitor, heavy chain 4 isoform 4 precursor
NM_018746.4 NP_061216.2 inter alpha-trypsin inhibitor, heavy chain 4 isoform 1 precursor
NM_001159299.2 NP_001152771.1 inter alpha-trypsin inhibitor, heavy chain 4 isoform 2 precursor
NM_001289632.1 NP_001276561.1 inter alpha-trypsin inhibitor, heavy chain 4 isoform 3 precursor
NM_001289633.1 NP_001276562.1 inter alpha-trypsin inhibitor, heavy chain 4 isoform 4 precursor
NM_018746.4 NP_061216.2 inter alpha-trypsin inhibitor, heavy chain 4 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
NOT enables calcium ion binding IDA
IDA: Inferred from direct assay
11803570 MGI
NOT enables hyaluronic acid binding IDA
IDA: Inferred from direct assay
11803570 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16271702 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11803570 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11803570 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inter alpha-trypsin inhibitor, heavy chain 4

ITI heavy chain H4

inter-alpha-inhibitor heavy chain 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06977 ITIH4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22578 Itih4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itih4 NCBI NCBI:3700