2. Gene
  3. Itgb2 - integrin beta 2 Gene

Itgb2 - integrin beta 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 2E6; LAD; Cd18; Lfa1; MF17; LCAMB

Gene ID: 16414 | Gene type: protein coding

About Itgb2

Summary

Enables amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; endocytosis; and positive regulation of leukocyte adhesion to vascular endothelial cell. Acts upstream of or within several processes, including activated T cell proliferation; integrin-mediated signaling pathway; and leukocyte migration. Located in external side of plasma membrane and membrane raft. Part of Integrin alphaM-beta2 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (Integrin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Itgb2 Products(1)

mRNA Protein Name
NM_008404.5 NP_032430.2 integrin beta-2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables amyloid-beta binding IMP
IMP: Inferred from mutant phenotype
18981818 MGI
contributes to cargo receptor activity IMP
IMP: Inferred from mutant phenotype
20199584 MGI
enables complement component C3b binding IGI
IGI: Inferred from genetic interaction
20199584 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19234461 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
15210787 MGI
involved in amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
20199584 MGI
acts upstream of or within cell adhesion IGI
IGI: Inferred from genetic interaction
19342649 MGI
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
10528208 MGI
acts upstream of or within cell-cell adhesion IGI
IGI: Inferred from genetic interaction
16093349 MGI
involved in cell-cell adhesion IGI
IGI: Inferred from genetic interaction
12652296 MGI
acts upstream of or within cellular extravasation IMP
IMP: Inferred from mutant phenotype
10528208 MGI
involved in cellular response to low-density lipoprotein particle stimulus IDA
IDA: Inferred from direct assay
23395392 MGI
acts upstream of or within integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
15249579 MGI
acts upstream of or within neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
10528208 MGI
involved in phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
20199584 MGI
involved in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
IMP: Inferred from mutant phenotype
24458438 MGI
involved in receptor internalization IDA
IDA: Inferred from direct assay
23395392 MGI
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
20199584 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
17023661 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19299737 MGI
part of integrin alphaM-beta2 complex IMP
IMP: Inferred from mutant phenotype
20199584 MGI
located in membrane IDA
IDA: Inferred from direct assay
10601245 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
10601245 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin beta-2

Mac-1 beta

cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta

complement receptor C3 subunit beta

lymphocyte function associated antigen 1

macrophage antigen-1 beta

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06965 ITGB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16847 Itgb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23288 Itgb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgb2 NCBI NCBI:3689