Itgb1 - integrin beta 1 (fibronectin receptor beta) Gene

Mus musculus

Also known as CD29; Fnrb; gpIIa; Gm9863; 4633401G24Rik

Gene ID: 16412 | Gene type: protein coding

About Itgb1

Summary

Enables Integrin binding activity. Contributes to laminin binding activity. Involved in several processes, including basement membrane organization; cellular response to low-density lipoprotein particle stimulus; and receptor internalization. Acts upstream of or within with a negative effect on reactive gliosis and regulation of spontaneous synaptic transmission. Acts upstream of or within several processes, including cell morphogenesis involved in differentiation; regulation of ion transmembrane transport; and striated muscle cell differentiation. Located in several cellular components, including Schaffer collateral - CA1 synapse; intercalated disc; and myelin sheath abaxonal region. Part of Integrin alpha7-beta1 complex. Is integral component of synaptic membrane. Colocalizes with cytoplasmic vesicle and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and limb. Used to study Hirschsprung's disease. Orthologous to human ITGB1 (Integrin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Itgb1 Products(1)

mRNA	Protein	Name
NM_010578.2	NP_034708.1	integrin beta-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	1833411	MGI
enables integrin binding involved in cell-matrix adhesion	IDA IDA: Inferred from direct assay	22654117	MGI
contributes to laminin binding	IDA IDA: Inferred from direct assay	1839357	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10613898	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	36812915	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12957148	MGI
acts upstream of or within axon extension	IGI IGI: Inferred from genetic interaction	12879062	MGI
acts upstream of or within axon extension	IMP IMP: Inferred from mutant phenotype	12879062	MGI
involved in basement membrane organization	IMP IMP: Inferred from mutant phenotype	24681597	MGI
acts upstream of or within cardiac cell fate specification	IMP IMP: Inferred from mutant phenotype	9004034	MGI
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	9004034	MGI
acts upstream of or within cardiac muscle cell myoblast differentiation	IMP IMP: Inferred from mutant phenotype	9004034	MGI
acts upstream of or within cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	16424942	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15056720	MGI
acts upstream of or within cell-matrix adhesion	IGI IGI: Inferred from genetic interaction	17099249	MGI
acts upstream of or within cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	21185282	MGI
involved in cellular response to low-density lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	23395392	MGI
acts upstream of or within dendrite morphogenesis	IGI IGI: Inferred from genetic interaction	22357865	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	22357865	MGI
acts upstream of or within formation of radial glial scaffolds	IMP IMP: Inferred from mutant phenotype	21185282	MGI
acts upstream of or within germ cell migration	IMP IMP: Inferred from mutant phenotype	10079228	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	7544313	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	17065460	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17065460	MGI
acts upstream of or within myoblast fate specification	IMP IMP: Inferred from mutant phenotype	9004034	MGI
acts upstream of or within negative regulation of Rho protein signal transduction	IGI IGI: Inferred from genetic interaction	22357865	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15056720	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15056720	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15056720	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	19118221	MGI
acts upstream of or within positive regulation of glutamate uptake involved in transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	25716834	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15056720	MGI
acts upstream of or within negative effect reactive gliosis	IMP IMP: Inferred from mutant phenotype	25716834	MGI
involved in receptor internalization	IDA IDA: Inferred from direct assay	23395392	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	14522949	MGI
acts upstream of or within regulation of inward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	25716834	MGI
acts upstream of or within negative effect regulation of spontaneous synaptic transmission	IMP IMP: Inferred from mutant phenotype	25716834	MGI
involved in regulation of synapse pruning	IDA IDA: Inferred from direct assay	24831527	MGI
involved in regulation of synapse pruning	IMP IMP: Inferred from mutant phenotype	24831527	MGI
involved in response to muscle activity	IDA IDA: Inferred from direct assay	36812915	MGI
acts upstream of or within sarcomere organization	IMP IMP: Inferred from mutant phenotype	9004034	MGI
NOT involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	24036928	MGI
NOT involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24036928	MGI
acts upstream of or within visual learning	IGI IGI: Inferred from genetic interaction	22357865	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	22357865	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	17065460	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	17065460	MGI
located in cell surface	IDA IDA: Inferred from direct assay	8306881	MGI
is active in cerebellar climbing fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	24831527	MGI
is active in cerebellar climbing fiber to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	24831527	MGI
colocalizes with cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12189152	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	22357865	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9553049	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16467530	MGI
part of integrin alpha7-beta1 complex	IDA IDA: Inferred from direct assay	18611855	MGI
part of integrin alpha7-beta1 complex	IPI IPI: Inferred from physical interaction	1839357	MGI
part of integrin alpha9-beta1 complex	IDA IDA: Inferred from direct assay	22654117	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	11732910	MGI
located in membrane	IDA IDA: Inferred from direct assay	23395392	MGI
located in myelin sheath abaxonal region	IDA IDA: Inferred from direct assay	20237282	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	9415431	MGI
colocalizes with perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12189152	MGI
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	12189152	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	36812915	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12591243	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	9415431	MGI
located in synapse	IDA IDA: Inferred from direct assay	12904471	MGI
is active in synaptic membrane	IDA IDA: Inferred from direct assay	16467530	MGI
located in synaptic membrane	IDA IDA: Inferred from direct assay	22357865	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

integrin beta-1

VLA-4 subunit beta

fibronectin receptor subunit beta

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990643	OS-2966	Inhibitor	99.62%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70297	N-Acetylglucosaminyltransferase IVa		/	Unkown
HY-RS06963	ITGB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06964	ITGB1BP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itgb1	NCBI	NCBI:3688
Macaca fascicularis	Itgb1	NCBI	NCBI:102144610

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