Itgam - integrin alpha M Gene

Mus musculus

Also known as CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik

Gene ID: 16409 | Gene type: protein coding

About Itgam

Summary

Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of Integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (Integrin subunit alpha M). [provided by Alliance of Genome Resources, Apr 2022]

Itgam Products(3)

mRNA	Protein	Name
NM_001082960.1	NP_001076429.1	integrin alpha-M isoform 1 precursor
NM_008401.2	NP_032427.2	integrin alpha-M isoform 2 precursor
NM_008401.2	NP_032427.2	integrin alpha-M isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cargo receptor activity	IGI IGI: Inferred from genetic interaction	22438044	MGI
contributes to cargo receptor activity	IMP IMP: Inferred from mutant phenotype	20199584	MGI
enables complement component C3b binding	IGI IGI: Inferred from genetic interaction	20199584	MGI
enables heparan sulfate proteoglycan binding	IDA IDA: Inferred from direct assay	8043862	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	8043862	MGI
enables opsonin binding	IDA IDA: Inferred from direct assay	12163569	MGI
enables opsonin binding	IMP IMP: Inferred from mutant phenotype	12163569	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	28228282	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	15210787	MGI
involved in amyloid-beta clearance	IGI IGI: Inferred from genetic interaction	20199584	MGI
involved in amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	22438044	MGI
acts upstream of or within cell adhesion	IGI IGI: Inferred from genetic interaction	19342649	MGI
acts upstream of or within cell adhesion	IMP IMP: Inferred from mutant phenotype	10528208	MGI
acts upstream of or within cell-cell adhesion	IGI IGI: Inferred from genetic interaction	16093349	MGI
acts upstream of or within cellular extravasation	IMP IMP: Inferred from mutant phenotype	10528208	MGI
involved in complement receptor mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22632727	MGI
involved in complement-mediated synapse pruning	IMP IMP: Inferred from mutant phenotype	22632727	MGI
involved in forebrain development	IDA IDA: Inferred from direct assay	18685038	MGI
involved in leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	8986723	MGI
acts upstream of or within leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	8562500	MGI
acts upstream of or within leukocyte migration involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	23550035	MGI
acts upstream of or within microglia development	IDA IDA: Inferred from direct assay	20578039	MGI
involved in microglial cell activation	IMP IMP: Inferred from mutant phenotype	18981141	MGI
involved in negative regulation of dopamine metabolic process	IDA IDA: Inferred from direct assay	18981141	MGI
involved in neutrophil apoptotic process	IMP IMP: Inferred from mutant phenotype	8986723	MGI
acts upstream of or within neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	10528208	MGI
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	8986723	MGI
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	20199584	MGI
involved in positive regulation of mast cell differentiation	IMP IMP: Inferred from mutant phenotype	9862668	MGI
involved in positive regulation of microglial cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	18685038	MGI
involved in positive regulation of prostaglandin-E synthase activity	IMP IMP: Inferred from mutant phenotype	18981141	MGI
involved in positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	18981141	MGI
involved in positive regulation of superoxide anion generation	IDA IDA: Inferred from direct assay	18685038	MGI
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	18981141	MGI
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	20199584	MGI
involved in vertebrate eye-specific patterning	IMP IMP: Inferred from mutant phenotype	22632727	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	9324354	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8043862	MGI
part of integrin alphaM-beta2 complex	IMP IMP: Inferred from mutant phenotype	20199584	MGI
located in membrane	IDA IDA: Inferred from direct assay	12529407	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15138196	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8986723	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

integrin alpha-M

CD11 antigen-like family member B	CD11B (p170)
CR-3 alpha chain	Mac-1 alpha
cell surface glycoprotein MAC-1 alpha subunit	cell surface glycoprotein MAC-1 subunit alpha
complement receptor type 3	leukocyte adhesion receptor MO1
macrophage antigen a

Itgam Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80592	CD11b Antibody	WB, IP	Mouse

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS20044	Itgam Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06960	ITGAM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26547	Itgam Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itgam	NCBI	NCBI:3684

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