2. Gene
  3. Itga3 - integrin alpha 3 Gene

Itga3 - integrin alpha 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CD49C; GAPB3

Gene ID: 16400 | Gene type: protein coding

About Itga3

Summary

This gene encodes a subunit of Integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the Integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Itga3 Products(3)

mRNA Protein Name
NM_001306071.1 NP_001293000.1 integrin alpha-3 isoform 2
NM_001306162.1 NP_001293091.1 integrin alpha-3 isoform 3 precursor
NM_013565.3 NP_038593.1 integrin alpha-3 isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12904471 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of Rho protein signal transduction IGI
IGI: Inferred from genetic interaction
23595732 MGI
acts upstream of or within behavior IMP
IMP: Inferred from mutant phenotype
23595732 MGI
acts upstream of or within dendritic spine maintenance IGI
IGI: Inferred from genetic interaction
23595732 MGI
acts upstream of or within dendritic spine maintenance IMP
IMP: Inferred from mutant phenotype
23595732 MGI
acts upstream of or within exploration behavior IGI
IGI: Inferred from genetic interaction
23595732 MGI
NOT acts upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization IMP
IMP: Inferred from mutant phenotype
12591243 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
12904471 MGI
acts upstream of or within negative regulation of Rho protein signal transduction IGI
IGI: Inferred from genetic interaction
23595732 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15091337 MGI
involved in postsynapse organization IDA
IDA: Inferred from direct assay
29091766 MGI
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
29091766 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
28386022 MGI
involved in synaptic membrane adhesion IMP
IMP: Inferred from mutant phenotype
28386022 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
7534781 MGI
located in excitatory synapse IDA
IDA: Inferred from direct assay
23595732 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9553049 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
29091766 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
29091766 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
28386022 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
28386022 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14566019 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
28386022 MGI
located in synapse IDA
IDA: Inferred from direct assay
12904471 MGI
located in synaptic membrane IDA
IDA: Inferred from direct assay
23595732 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-3

CD49 antigen-like family member C

VLA-3 receptor, alpha 3 subunit

galactoprotein B3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06950 ITGA3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20968 Itga3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27485 Itga3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga3 NCBI NCBI:3675