Irf1 - interferon regulatory factor 1 Gene

Mus musculus

Also known as Irf-1

Gene ID: 16362 | Gene type: protein coding

About Irf1

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including defense response to Other organism; regulation of T cell activation; and regulation of gene expression. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation; positive regulation of interleukin-12 production; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; lung non-small cell carcinoma; and smallpox. Orthologous to human IRF1 (interferon regulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Irf1 Products(3)

mRNA	Protein	Name
NM_001159393.1	NP_001152865.1	interferon regulatory factor 1 isoform b
NM_001159396.1	NP_001152868.1	interferon regulatory factor 1 isoform a
NM_008390.2	NP_032416.1	interferon regulatory factor 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14568984	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14568984	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	25774715	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	30635240	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17018642	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17159910	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within CD8-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	11359801	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	20451243	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18641303	MGI
involved in negative regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	18641303	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14568984	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20308629	MGI
acts upstream of or within positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	14568984	MGI
acts upstream of or within positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	14568984	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17159910	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	30635240	MGI
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	17018642	MGI
involved in regulation of CD8-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	21909274	MGI
involved in regulation of MyD88-dependent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17018642	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11359801	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17159910	MGI
involved in type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21909274	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17018642	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17018642	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	30635240	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interferon regulatory factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171006	IRF1-IN-1	Inhibitor	99.72%	Unkown
HY-133897	(Rac)-Indoximod		99.18%	Unkown
HY-108052	Delphinidin 3-glucoside chloride		99.89%	Unkown
HY-Y0148	10-Hydroxydecanoic acid	Inhibitor	98.77%	Unkown
HY-171007	IRF1-IN-2		99.83%	Unkown
HY-RS06902	IRF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16716	Irf1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23151	Irf1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irf1	NCBI	NCBI:3659

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