Irak1 - interleukin-1 receptor-associated kinase 1 Gene

Mus musculus

Also known as IRAK; Plpk; mPLK; IRAK-1; IRAK1b; Il1rak; IRAK1-S

Gene ID: 16179 | Gene type: protein coding

About Irak1

Chromosome X: 73,057,520-73,067,524 reverse strand.GRCm39:CM001013.3

This gene has 22 transcripts (splice variants), 187 orthologues, 4 paralogues and is associated with 6 phenotypes. Ubiquitous expression in adrenal adult (RPKM 73.), ovary adult (RPKM 47.6) and 27 other tissues.

Summary

Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in negative regulation of Cholesterol efflux; negative regulation of transcription, DNA-templated; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including interleukin-1-mediated signaling pathway; response to molecule of Bacterial origin; and Toll-like Receptor signaling pathway. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including liver; skeletal muscle; and urinary system. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Irak1 Products(5)

mRNA	Protein	Name
NM_001177973.1	NP_001171444.1	interleukin-1 receptor-associated kinase 1 isoform 1
NM_001177974.1	NP_001171445.1	interleukin-1 receptor-associated kinase 1 isoform 4
NM_008363.2	NP_032389.2	interleukin-1 receptor-associated kinase 1 isoform 4
NM_001177975.1	NP_001171446.1	interleukin-1 receptor-associated kinase 1 isoform 3
NM_001177976.1	NP_001171447.1	interleukin-1 receptor-associated kinase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-1 receptor binding	IPI IPI: Inferred from physical interaction	15292196	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10854325	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	10549626	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	15292196	MGI
involved in innate immune response	IEP IEP: Inferred from expression pattern	16831874	MGI
acts upstream of or within interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	12054681	MGI
involved in interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	10854325	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	10549626	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19752193	MGI
involved in negative regulation of cholesterol efflux	IMP IMP: Inferred from mutant phenotype	19752193	MGI
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	17379480	MGI
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17379480	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	12054681	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	10549626	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	10549626	MGI
acts upstream of or within response to peptidoglycan	IDA IDA: Inferred from direct assay	10549626	MGI
acts upstream of or within toll-like receptor 2 signaling pathway	IDA IDA: Inferred from direct assay	10549626	MGI
acts upstream of or within toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	10549626	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in lipid droplet	IDA IDA: Inferred from direct assay	21435586	MGI
located in membrane	IDA IDA: Inferred from direct assay	16831874	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	10854325	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Irak1 Protein Structure

Death_IRAK1

PKc_like

0
200
400
600
711 a.a.

Protein Preferred Names

Protein Names

interleukin-1 receptor-associated kinase 1

interleukin-1 receptor-associated kinase-1b

pelle-like protein kinase

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-160487	KME-2780	Inhibitor	98.94%	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0039	Ginsenoside Rb1	Inhibitor	98.75%	Unkown
HY-103017A	JH-X-119-01	Inhibitor	99.03%	Unkown
HY-147141	HS-276	Inhibitor	98.59%	Unkown
HY-111101	AZ1495	Inhibitor	98.07%	Unkown
HY-103017	JH-X-119-01 hydrochloride	Inhibitor	99.14%	Unkown
HY-153188	JNJ-1013	Degrader	99.80%	Unkown
HY-134911	HS-243	Inhibitor	99.95%	Unkown
HY-153224	GLPG2534	Inhibitor	98.73%	Unkown
HY-153110A	Larotinib mesylate hydrate	Inhibitor	98.66%	Unkown
HY-159953	IRAK1/4/pan-FLT3 Kinase-IN-1	Inhibitor	/	Unkown
HY-153110	Larotinib	Inhibitor	99.50%	Unkown
HY-N0039R	Ginsenoside Rb1 (Standard)	Inhibitor	/	Unkown
HY-162641	AF-45	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irak1	NCBI	NCBI:3654

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