Ihh - Indian hedgehog Gene

Mus musculus

Also known as HHG-2

Gene ID: 16147 | Gene type: protein coding

About Ihh

Summary

Enables patched binding activity. Involved in several processes, including heart looping; positive regulation of smoothened signaling pathway; and regulation of T cell differentiation. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of biosynthetic process. Located in extracellular matrix. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; limb; and skeleton. Used to study Hirschsprung's disease; annular pancreas; and brachydactyly type A1. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian Hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]

Ihh Products(2)

mRNA	Protein	Name
NM_001313683.1	NP_001300612.1	indian hedgehog protein isoform 2 precursor
NM_010544.3	NP_034674.2	indian hedgehog protein isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables patched binding	IPI IPI: Inferred from physical interaction	9811851	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10050855	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within bone resorption	IDA IDA: Inferred from direct assay	10208865	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15689378	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	18582859	MGI
acts upstream of or within camera-type eye photoreceptor cell fate commitment	IMP IMP: Inferred from mutant phenotype	18582859	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	17191253	MGI
acts upstream of or within cell fate specification	IMP IMP: Inferred from mutant phenotype	18582859	MGI
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	15576404	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16284117	MGI
acts upstream of or within chondrocyte differentiation	IDA IDA: Inferred from direct assay	15951842	MGI
acts upstream of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16284117	MGI
acts upstream of or within chondrocyte differentiation involved in endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	25639508	MGI
acts upstream of or within chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	16935278	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	17881493	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	18582859	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	10821773	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	20660756	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	20660756	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	18582859	MGI
acts upstream of or within embryonic skeletal joint development	IMP IMP: Inferred from mutant phenotype	17191253	MGI
involved in endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	10465785	MGI
acts upstream of or within epithelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	18582859	MGI
acts upstream of or within epithelial cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18582859	MGI
acts upstream of or within head morphogenesis	IMP IMP: Inferred from mutant phenotype	16935278	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17881493	MGI
acts upstream of or within morphogenesis of a branching structure	IMP IMP: Inferred from mutant phenotype	11044404	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	10821773	MGI
involved in negative regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	19109233	MGI
involved in negative regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	19109233	MGI
acts upstream of or within negative regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16284117	MGI
acts upstream of or within negative regulation of eye pigmentation	IMP IMP: Inferred from mutant phenotype	17464332	MGI
involved in negative regulation of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	19109233	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	10821773	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	11748145	MGI
acts upstream of or within osteoblast differentiation	IDA IDA: Inferred from direct assay	25639508	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	25639508	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	14973297	MGI
acts upstream of or within pancreas development	IGI IGI: Inferred from genetic interaction	11044404	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	10821773	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	9671585	MGI
involved in positive regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	19109233	MGI
involved in positive regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	19109233	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	17191253	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16284117	MGI
acts upstream of or within positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	10208865	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	18582859	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17881493	MGI
acts upstream of positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within proteoglycan metabolic process	IGI IGI: Inferred from genetic interaction	16935278	MGI
acts upstream of or within regulation of growth	IGI IGI: Inferred from genetic interaction	19590577	MGI
acts upstream of or within retinal pigment epithelium development	IMP IMP: Inferred from mutant phenotype	18582859	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	16278811	MGI
acts upstream of or within smooth muscle tissue development	IMP IMP: Inferred from mutant phenotype	10821773	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: Inferred from direct assay	25639508	MGI
acts upstream of or within smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	19590577	MGI
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	11517919	MGI
involved in somite development	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	17881493	MGI
acts upstream of or within vitelline membrane formation	IMP IMP: Inferred from mutant phenotype	17881493	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	11476578	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

indian hedgehog protein

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0338A	Rimantadine hydrochloride		≥98.0%	Unkown
HY-B0338	Rimantadine		99.86%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06654	IHH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17797	Ihh Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24265	Ihh Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ihh	NCBI	NCBI:3549

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