2. Gene
  3. Igfbp3 - insulin-like growth factor binding protein 3 Gene

Igfbp3 - insulin-like growth factor binding protein 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IGFBP-3; IGgfbp3

Gene ID: 16009 | Gene type: protein coding

About Igfbp3

Summary

Enables fibronectin binding activity and insulin-like growth factor binding activity. Acts upstream of or within several processes, including osteoblast differentiation; positive regulation of signal transduction; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; early embryo; gonad; and limb. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (Insulin like growth factor binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Igfbp3 Products(1)

mRNA Protein Name
NM_008343.2 NP_032369.2 insulin-like growth factor-binding protein 3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables fibronectin binding IDA
IDA: Inferred from direct assay
19236847 MGI
enables insulin-like growth factor binding IPI
IPI: Inferred from physical interaction
7679139 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of MAPK cascade IGI
IGI: Inferred from genetic interaction
16675541 MGI
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
16311053 MGI
acts upstream of or within positive regulation of MAPK cascade IGI
IGI: Inferred from genetic interaction
16675541 MGI
acts upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16675541 MGI
acts upstream of or within regulation of cell growth IGI
IGI: Inferred from genetic interaction
16675541 MGI
acts upstream of or within regulation of glucose metabolic process IGI
IGI: Inferred from genetic interaction
16675541 MGI
acts upstream of or within regulation of growth IGI
IGI: Inferred from genetic interaction
16675541 MGI
acts upstream of or within type B pancreatic cell proliferation IGI
IGI: Inferred from genetic interaction
16675541 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
7510770 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-like growth factor-binding protein 3

IBP-3

IGF-binding protein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W074890 Palmitoylglycine Modulator 99.74% Unkown
HY-N3316 Martynoside Antagonist ≥99.0% Unkown
HY-110135A NBI-31772 hydrate Inhibitor 99.42% Unkown
HY-RS06626 IGFBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10403 IGFBP-3 peptide / Unkown
HY-RS17430 Igfbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23885 Igfbp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igfbp3 NCBI NCBI:3486