Igf2 - insulin-like growth factor 2 Gene

Mus musculus

Also known as Mpr; M6pr; Peg2; Igf-2; Igf-II

Gene ID: 16002 | Gene type: protein coding

About Igf2

Summary

This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Igf2 Products(5)

mRNA	Protein	Name
NM_001122736.2	NP_001116208.1	insulin-like growth factor II isoform 2 preproprotein
NM_001122737.2	NP_001116209.1	insulin-like growth factor II isoform 2 preproprotein
NM_001315488.1	NP_001302417.1	insulin-like growth factor II isoform 2 preproprotein
NM_001315489.1	NP_001302418.1	insulin-like growth factor II isoform 2 preproprotein
NM_010514.3	NP_034644.2	insulin-like growth factor II isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables insulin-like growth factor receptor binding	IPI IPI: Inferred from physical interaction	14566968	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14566968	MGI
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	20032056	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	29348399	MGI
enables receptor ligand activity	IGI IGI: Inferred from genetic interaction	9281335	MGI
enables receptor ligand activity	IMP IMP: Inferred from mutant phenotype	20032056	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	29348399	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IGI IGI: Inferred from genetic interaction	9281335	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	12101187	MGI
involved in embryonic placenta development	IMP IMP: Inferred from mutant phenotype	12087403	MGI
involved in embryonic placenta morphogenesis	IMP IMP: Inferred from mutant phenotype	28522536	MGI
acts upstream of or within exocrine pancreas development	IMP IMP: Inferred from mutant phenotype	12101187	MGI
involved in in utero embryonic development	IMP IMP: Inferred from mutant phenotype	28522536	MGI
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20032056	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	29348399	MGI
involved in insulin-like growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	9281335	MGI
involved in negative regulation of muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	32557799	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16901893	MGI
involved in osteoblast differentiation	IEP IEP: Inferred from expression pattern	16311053	MGI
acts upstream of positive regulation of glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	20032056	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	9203585	MGI
involved in positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	29440408	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	20032056	MGI
involved in positive regulation of skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	29440408	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18762576	MGI
involved in regulation of muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16901893	MGI
involved in spongiotrophoblast cell proliferation	IMP IMP: Inferred from mutant phenotype	22562201	MGI
acts upstream of or within striated muscle cell differentiation	IGI IGI: Inferred from genetic interaction	18762576	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18762576	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulin-like growth factor II

multiplication-stimulating polypeptide

Related Agents

Clinical Phase

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99294	Ganitumab	Inhibitor	96.00%	Phase 3
HY-P99274	Xentuzumab	Antagonist	99.71%	Phase 2
HY-P99284	Dalotuzumab		97.43%	Phase 2
HY-P99867	Dusigitumab		96.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153274	CWI1-2	Inducer	98.18%	Unkown
HY-144873	AVJ16	Inducer	99.60%	Unkown
HY-115449	Chromeceptin		99.80%	Unkown
HY-153274A	CWI1-2 hydrochloride	Inducer	98.27%	Unkown
HY-156110	IGF2BP1-IN-1	Inhibitor	99.94%	Unkown
HY-RS06622	IGF2R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17518	Igf2bp3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-176471	IGF2BP3-IN-1	Inhibitor	/	Unkown
HY-RS06618	IGF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06619	IGF2BP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06620	IGF2BP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06621	IGF2BP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06839	INS-IGF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16571	Igf2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16822	Igf2bp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16849	Igf2bp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17981	Igf2r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23004	Igf2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23262	Igf2bp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23290	Igf2bp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23975	Igf2bp3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24452	Igf2r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igf2	NCBI	NCBI:3481
Macaca mulatta	Igf2	NCBI	NCBI:710802

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