Ier3 - immediate early response 3 Gene

Mus musculus

Also known as cI-3; IEX-1; gly96

Gene ID: 15937 | Gene type: protein coding

About Ier3

Summary

Acts upstream of or within several processes, including intracellular signal transduction; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in brain; head; and placenta. Orthologous to human IER3 (immediate early response 3). [provided by Alliance of Genome Resources, Apr 2022]

Ier3 Products(1)

mRNA	Protein	Name
NM_133662.2	NP_598423.1	radiation-inducible immediate-early gene IEX-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19096392	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	20467439	MGI
acts upstream of glycolytic process	IMP IMP: Inferred from mutant phenotype	19096392	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	11753682	MGI
acts upstream of or within mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	20467439	MGI
acts upstream of or within negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	19096392	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	19923449	MGI
acts upstream of or within negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19096392	MGI
acts upstream of or within negative regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	16166241	MGI
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	19096392	MGI
acts upstream of or within regulation of DNA repair	IMP IMP: Inferred from mutant phenotype	20467439	MGI
acts upstream of or within regulation of nucleocytoplasmic transport	IMP IMP: Inferred from mutant phenotype	20467439	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19096392	MGI
acts upstream of or within response to protozoan	IMP IMP: Inferred from mutant phenotype	19923449	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	20467439	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

radiation-inducible immediate-early gene IEX-1

cAMP inducible gene 3	immediate early protein GLY96
immediate early response 3 protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06548	IER3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06549	IER3IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19341	Ier3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25832	Ier3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ier3	NCBI	NCBI:8870

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