Id3 - inhibitor of DNA binding 3 Gene

Mus musculus

Also known as Idb3; Hlh462; bHLHb25

Gene ID: 15903 | Gene type: protein coding

About Id3

Summary

Enables leptomycin B binding activity; protein domain specific binding activity; and transcription regulator inhibitor activity. Involved in negative regulation of myoblast differentiation; negative regulation of transcription, DNA-templated; and positive regulation of gene expression. Acts upstream of or within several processes, including animal organ development; cellular response to leptomycin B; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb; metanephros; and sensory organ. Used to study Sjogren's syndrome. Orthologous to human ID3 (inhibitor of DNA binding 3, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]

Id3 Products(1)

mRNA	Protein	Name
NM_008321.2	NP_032347.1	DNA-binding protein inhibitor ID-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	8759016	MGI
enables leptomycin B binding	IDA IDA: Inferred from direct assay	23523789	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8759016	MGI
enables protein domain specific binding	IDA IDA: Inferred from direct assay	2000388	MGI
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	17681138	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to leptomycin B	IDA IDA: Inferred from direct assay	23523789	MGI
involved in central nervous system development	IEP IEP: Inferred from expression pattern	7655079	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19217292	MGI
acts upstream of or within epithelial cell differentiation	IDA IDA: Inferred from direct assay	16407553	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	15472070	MGI
involved in metanephros development	IEP IEP: Inferred from expression pattern	7655079	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19217292	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	23523789	MGI
involved in negative regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	23824195	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	15161906	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	2000388	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19217292	MGI
involved in notochord development	IEP IEP: Inferred from expression pattern	7655079	MGI
involved in odontogenesis	IEP IEP: Inferred from expression pattern	7655079	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	17681138	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	17681138	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8083744	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	23523789	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA-binding protein inhibitor ID-3

ID-like protein inhibitor HLH 462

inhibitor of differentiation 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-110245	DMH2	Inducer	99.6%	Unkown
HY-143623S	Neo Spiramycin I-d3		/	Unkown
HY-155705	BMP agonist 1		/	Unkown
HY-RS06524	ID3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17523	Id3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23980	Id3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Id3	NCBI	NCBI:3399

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