2. Gene
  3. Ndst1 - N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 Gene

Ndst1 - N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Hsst; HSNST; N-HSST; NDST-1; HSNST 1; N-HSST 1; b2b2230Clo; 1200015G06Rik

Gene ID: 15531 | Gene type: protein coding

About Ndst1

Summary

Enables deacetylase activity and sulfotransferase activity. Acts upstream of or within several processes, including animal organ development; positive regulation of signal transduction; and protein sulfation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; future brain; integumental system; nervous system; and respiratory system. Used to study DiGeorge syndrome; congenital diaphragmatic hernia; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ndst1 Products(6)

mRNA Protein Name
NM_001348100.1 NP_001335029.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NM_001348101.1 NP_001335030.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NM_001348102.1 NP_001335031.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NM_001348103.1 NP_001335032.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NM_001348146.1 NP_001335075.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 2
NM_008306.5 NP_032332.2 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N-acetylglucosamine deacetylase activity IDA
IDA: Inferred from direct assay
11087757 MGI
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IDA
IDA: Inferred from direct assay
10758005 MGI
enables deacetylase activity IDA
IDA: Inferred from direct assay
11087757 MGI
enables heparan sulfate N-deacetylase activity IDA
IDA: Inferred from direct assay
10758005 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18337501 MGI
enables sulfotransferase activity IDA
IDA: Inferred from direct assay
11087757 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
10664446 MGI
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
26024086 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within embryo development IGI
IGI: Inferred from genetic interaction
16020517 MGI
acts upstream of or within embryonic neurocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
16020517 MGI
acts upstream of or within embryonic viscerocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
16020517 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16020517 MGI
acts upstream of or within forebrain development IGI
IGI: Inferred from genetic interaction
16020517 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
16020517 MGI
acts upstream of or within glycosaminoglycan metabolic process IMP
IMP: Inferred from mutant phenotype
16020517 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in heparan sulfate proteoglycan biosynthetic process IDA
IDA: Inferred from direct assay
18487608 MGI
involved in heparan sulfate proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
18385133 MGI
involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IDA
IDA: Inferred from direct assay
10758005 MGI
acts upstream of or within midbrain development IGI
IGI: Inferred from genetic interaction
16020517 MGI
acts upstream of or within polysaccharide biosynthetic process IMP
IMP: Inferred from mutant phenotype
10852901 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
16020517 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
16020517 MGI
acts upstream of or within protein sulfation IMP
IMP: Inferred from mutant phenotype
10852901 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: Inferred from mutant phenotype
10664446 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
11687650 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

N-heparan sulfate sulfotransferase 1

[Heparan sulfate]-glucosamine N-sulfotransferase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09118 NDST1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20062 Ndst1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26566 Ndst1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndst1 NCBI NCBI:3340