Hspg2 - perlecan (heparan sulfate proteoglycan 2) Gene

Mus musculus

Also known as Pcn; Plc; per; HSPG

Gene ID: 15530 | Gene type: protein coding

About Hspg2

Summary

Enables protease binding activity. Involved in receptor-mediated endocytosis. Acts upstream of or within several processes, including animal organ development; extracellular matrix organization; and skeletal system development. Located in basement membrane. Is expressed in several structures, including alimentary system; cardiovascular system; early conceptus; genitourinary system; and nervous system. Used to study Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; dextro-looped transposition of the great arteries; and thanatophoric dysplasia. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2). [provided by Alliance of Genome Resources, Apr 2022]

Hspg2 Products(1)

mRNA	Protein	Name
NM_008305.3	NP_032331.2	basement membrane-specific heparan sulfate proteoglycan core protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	22952693	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12243745	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	10579729	MGI
acts upstream of or within cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	10579729	MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	10545953	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10545953	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	10579729	MGI
acts upstream of or within endochondral ossification	IMP IMP: Inferred from mutant phenotype	10579729	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	10579729	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	11802174	MGI
involved in receptor-mediated endocytosis	IGI IGI: Inferred from genetic interaction	21289173	MGI
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	21289173	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	7670489	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	10579729	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

basement membrane-specific heparan sulfate proteoglycan core protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06449	HSPG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19691	Hspg2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26186	Hspg2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hspg2	NCBI	NCBI:3339

Name
Email *

	Sorry, but the email address you supplied was invalid.