2. Gene
  3. Hsd17b1 - hydroxysteroid (17-beta) dehydrogenase 1 Gene

Hsd17b1 - hydroxysteroid (17-beta) dehydrogenase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as E2DH; 17HSDB1; Hsd17ba; 17beta-HSD

Gene ID: 15485 | Gene type: protein coding

About Hsd17b1

Summary

Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity and testosterone dehydrogenase [NAD(P)] activity. Involved in estrogen biosynthetic process and testosterone biosynthetic process. Predicted to be located in cytosol. Is expressed in several structures, including adrenal gland; genitourinary system; spleen; submandibular gland; and trachea. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b1 Products(1)

mRNA Protein Name
NM_010475.2 NP_034605.1 17-beta-hydroxysteroid dehydrogenase type 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
9658408 MGI
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
9658408 MGI
enables testosterone dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
9658408 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adipose tissue development IMP
IMP: Inferred from mutant phenotype
29180785 MGI
involved in estrogen biosynthetic process IDA
IDA: Inferred from direct assay
9658408 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
29180785 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
29180785 MGI
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
29180785 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
29180785 MGI
involved in testosterone biosynthetic process IDA
IDA: Inferred from direct assay
9658408 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

17-beta-hydroxysteroid dehydrogenase type 1

estradiol 17-beta-dehydrogenase 1

17-beta-HSD 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-129583 Lepidiline A Activator 99.87% Unkown
HY-159525 Linustedastatum Inhibitor / Unkown
HY-RS06389 HSD17B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19278 Hsd17b1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25768 Hsd17b1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd17b1 NCBI NCBI:3292