Hspa8 - heat shock protein 8 Gene

Mus musculus

Also known as Hsc70; Hsc71; Hsc73; Hsp73; Hspa10; 2410008N15Rik

Gene ID: 15481 | Gene type: protein coding

About Hspa8

Summary

Enables ATP hydrolysis activity; phosphatidylserine binding activity; and unfolded protein binding activity. Involved in several processes, including chaperone-mediated protein folding; late endosomal microautophagy; and positive regulation by host of viral genome replication. Acts upstream of or within several processes, including chaperone cofactor-dependent protein refolding; clathrin coat disassembly; and positive regulation of mRNA splicing, via spliceosome. Located in several cellular components, including extracellular exosome; glycinergic synapse; and photoreceptor ribbon synapse. Is active in presynapse. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; brain; eye; and forelimb long bone. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (HSP70) member 8). [provided by Alliance of Genome Resources, Apr 2022]

Hspa8 Products(2)

mRNA	Protein	Name
NM_001364480.1	NP_001351409.1	heat shock cognate 71 kDa protein isoform 2
NM_031165.5	NP_112442.2	heat shock cognate 71 kDa protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	12588994	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	21238931	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12588994	MGI
enables unfolded protein binding	IPI IPI: Inferred from physical interaction	12588994	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chaperone cofactor-dependent protein refolding	IGI IGI: Inferred from genetic interaction	14644449	MGI
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	21151134	MGI
involved in chaperone-mediated protein folding	IEP IEP: Inferred from expression pattern	21151134	MGI
involved in chaperone-mediated protein folding	IMP IMP: Inferred from mutant phenotype	21151134	MGI
involved in clathrin coat disassembly	IDA IDA: Inferred from direct assay	8524399	MGI
acts upstream of or within clathrin coat disassembly	IGI IGI: Inferred from genetic interaction	20160091	MGI
involved in late endosomal microautophagy	IMP IMP: Inferred from mutant phenotype	21238931	MGI
involved in modulation by host of viral process	IMP IMP: Inferred from mutant phenotype	26581985	MGI
involved in positive regulation by host of viral genome replication	IMP IMP: Inferred from mutant phenotype	26581985	MGI
acts upstream of or within positive regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	23636947	MGI
acts upstream of or within protein folding	IDA IDA: Inferred from direct assay	12588994	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	12588994	MGI
involved in regulation of postsynapse organization	EXP EXP: Inferred from Experiment	28234934	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	28234934	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26581985	MGI
located in cytosol	IDA IDA: Inferred from direct assay	16906134	MGI
located in extracellular exosome	IDA IDA: Inferred from direct assay	19724054	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	28234934	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21209184	MGI
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	21209184	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	9122205	MGI
located in late endosome	IDA IDA: Inferred from direct assay	21238931	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14627652	MGI
is active in photoreceptor ribbon synapse	IDA IDA: Inferred from direct assay	24616664	MGI
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	21209184	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	21151134	MGI
is active in presynapse	IEP IEP: Inferred from expression pattern	21151134	MGI
is active in presynapse	IMP IMP: Inferred from mutant phenotype	21151134	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heat shock cognate 71 kDa protein

heat shock 70 kDa protein 8	heat shock cognate hsc73
heat shock protein cognate 70

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111002	Displurigen	Inhibitor	98.48%	Unkown
HY-RS17202	Hspa8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06436	HSPA8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23654	Hspa8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hspa8	NCBI	NCBI:3312

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