Prmt2 - protein arginine N-methyltransferase 2 Gene

Mus musculus

Also known as Hrmt1l1

Gene ID: 15468 | Gene type: protein coding

About Prmt2

Summary

Enables beta-catenin binding activity and histone-arginine N-methyltransferase activity. Involved in several processes, including histone methylation; negative regulation of G1/S transition of mitotic cell cycle; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PRMT2 (protein arginine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Prmt2 Products(3)

mRNA	Protein	Name
NM_001077638.2	NP_001071106.1	protein arginine N-methyltransferase 2 isoform 2
NM_001302965.1	NP_001289894.1	protein arginine N-methyltransferase 2 isoform 1
NM_133182.3	NP_573445.2	protein arginine N-methyltransferase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	20708585	MGI
enables histone H3 methyltransferase activity	IDA IDA: Inferred from direct assay	20708585	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16616919	MGI
enables protein-arginine N-methyltransferase activity	IMP IMP: Inferred from mutant phenotype	20798359	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16616919	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in developmental cell growth	IMP IMP: Inferred from mutant phenotype	20798359	MGI
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	16616919	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16616919	MGI
involved in negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16616919	MGI
involved in response to hypoxia	IDA IDA: Inferred from direct assay	16690984	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 2

heterogeneous nuclear ribonucleoprotein methyltransferase-like 1

histone-arginine N-methyltransferase PRMT2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11170	PRMT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19732	Prmt2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26228	Prmt2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prmt2	NCBI	NCBI:3275

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