2. Gene
  3. Hoxa1 - homeobox A1 Gene

Hoxa1 - homeobox A1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ERA1; Hox-1.6

Gene ID: 15394 | Gene type: protein coding

About Hoxa1

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cellular response to ethanol; cellular response to retinoic acid; and nervous system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; embryo ectoderm; embryo mesenchyme; genitourinary system; and gut. Used to study Athabaskan brainstem dysgenesis syndrome. Human ortholog(s) of this gene implicated in Athabaskan brainstem dysgenesis syndrome and autistic disorder. Orthologous to human HOXA1 (homeobox A1). [provided by Alliance of Genome Resources, Apr 2022]

Hoxa1 Products(2)

mRNA Protein Name
NM_001311118.1 NP_001298047.1 homeobox protein Hox-A1 isoform 2
NM_010449.4 NP_034579.3 homeobox protein Hox-A1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23088713 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: Inferred from genetic interaction
10529420 MGI
acts upstream of or within anatomical structure morphogenesis IGI
IGI: Inferred from genetic interaction
10529420 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
10529420 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
15367676 MGI
acts upstream of or within cellular response to ethanol IEP
IEP: Inferred from expression pattern
19091803 MGI
acts upstream of or within cellular response to retinoic acid IDA
IDA: Inferred from direct assay
23723417 MGI
acts upstream of or within central nervous system neuron differentiation IMP
IMP: Inferred from mutant phenotype
9806922 MGI
acts upstream of or within facial nerve structural organization IGI
IGI: Inferred from genetic interaction
9806922 MGI
acts upstream of or within facial nucleus development IMP
IMP: Inferred from mutant phenotype
8102800 MGI
acts upstream of or within hindbrain development IMP
IMP: Inferred from mutant phenotype
15367676 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
15367676 MGI
acts upstream of or within motor neuron axon guidance IGI
IGI: Inferred from genetic interaction
9806922 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
15367676 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18787068 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15465489 MGI
acts upstream of or within rhombomere 3 development IGI
IGI: Inferred from genetic interaction
9806922 MGI
acts upstream of or within rhombomere 3 development IMP
IMP: Inferred from mutant phenotype
9806922 MGI
acts upstream of or within rhombomere 4 development IGI
IGI: Inferred from genetic interaction
10529420 MGI
acts upstream of or within rhombomere 4 development IMP
IMP: Inferred from mutant phenotype
8102800 MGI
acts upstream of or within rhombomere 5 development IGI
IGI: Inferred from genetic interaction
10529420 MGI
acts upstream of or within rhombomere 5 development IMP
IMP: Inferred from mutant phenotype
8102800 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Hox-A1

early retinoic acid 1

homeobox protein Hox-1.6

homeoboxless protein ERA-1-399

homeotic protein ERA-1-993

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06293 HOXA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18666 Hoxa1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25152 Hoxa1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hoxa1 NCBI NCBI:3198