Hnf4a - hepatic nuclear factor 4, alpha Gene

Mus musculus

Also known as Hnf4; HNF-4; MODY1; Nr2a1; Tcf14; TCF-14; Hnf4alpha

Gene ID: 15378 | Gene type: protein coding

About Hnf4a

Summary

The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Hnf4a Products(3)

mRNA	Protein	Name
NM_001312906.1	NP_001299835.1	hepatocyte nuclear factor 4-alpha isoform HNF4alpha11
NM_001312907.1	NP_001299836.1	hepatocyte nuclear factor 4-alpha isoform HNF4alpha10
NM_008261.3	NP_032287.2	hepatocyte nuclear factor 4-alpha isoform HNF4alpha2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15014077	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	27471003	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15761495	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10859308	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22589549	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17932483	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22780989	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17636037	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8306889	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	15761495	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	11158324	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	15761495	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	16498401	MGI
involved in phospholipid homeostasis	IMP IMP: Inferred from mutant phenotype	11158324	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9408084	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	30555544	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10859308	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15761495	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17636037	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16537911	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11158324	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9053305	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	30530698	MGI
acts upstream of or within regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	7958910	MGI
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	15761495	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22589549	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22589549	MGI
involved in response to glucose	IMP IMP: Inferred from mutant phenotype	15761495	MGI
acts upstream of or within sex differentiation	IMP IMP: Inferred from mutant phenotype	17412818	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10859308	MGI
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	11158324	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8306889	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 4-alpha

HNF4 alpha	Nuclear receptor 2A1
nuclear receptor subfamily 2 group A member 1	transcription factor 14
transcription factor HNF-4

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06257	HNF4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17608	Hnf4a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06255	HNF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24068	Hnf4a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnf4a	NCBI	NCBI:3172

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