2. Gene
  3. Hmgcl - 3-hydroxy-3-methylglutaryl-Coenzyme A lyase Gene

Hmgcl - 3-hydroxy-3-methylglutaryl-Coenzyme A lyase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HL

Gene ID: 15356 | Gene type: protein coding

About Hmgcl

Summary

Predicted to enable several functions, including fatty-acyl-CoA binding activity; hydroxymethylglutaryl-CoA lyase activity; and metal ion binding activity. Acts upstream of or within mitochondrion organization. Located in mitochondrion. Is expressed in alimentary system; cranium; and liver. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcl Products(3)

mRNA Protein Name
NM_001357529.1 NP_001344458.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 2
NM_001357530.1 NP_001344459.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 3
NM_008254.3 NP_032280.2 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
9817922 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
9817922 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
26767982 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hydroxymethylglutaryl-CoA lyase, mitochondrial

3-hydroxy-3-methylglutarate-CoA lyase

HMG-CoA lyase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06236 HMGCL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20953 Hmgcl Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27470 Hmgcl Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgcl NCBI NCBI:3155