Mnx1 - motor neuron and pancreas homeobox 1 Gene

Mus musculus

Also known as HB9; MNR2; Hlxb9

Gene ID: 15285 | Gene type: protein coding

About Mnx1

Summary

Predicted to enable sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including diaphragm development; endocrine pancreas development; and nervous system development. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; lung epithelium; and notochord. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Mnx1 Products(1)

mRNA	Protein	Name
NM_019944.2	NP_064328.2	motor neuron and pancreas homeobox protein 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell morphogenesis involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	10482234	MGI
acts upstream of or within central nervous system neuron differentiation	IMP IMP: Inferred from mutant phenotype	10482234	MGI
acts upstream of or within diaphragm development	IMP IMP: Inferred from mutant phenotype	10482234	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IDA IDA: Inferred from direct assay	18590716	MGI
acts upstream of or within endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	10471501	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	10482234	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18539116	MGI
acts upstream of or within nerve development	IMP IMP: Inferred from mutant phenotype	11395002	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	11395002	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	10482234	MGI
acts upstream of or within neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	10482234	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	10471501	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	10482234	MGI
acts upstream of or within respiratory system development	IMP IMP: Inferred from mutant phenotype	10482234	MGI
acts upstream of or within spinal cord motor neuron cell fate specification	IMP IMP: Inferred from mutant phenotype	10482234	MGI
involved in spinal cord motor neuron cell fate specification	IMP IMP: Inferred from mutant phenotype	18539116	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	18539116	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17042795	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

motor neuron and pancreas homeobox protein 1

homeobox gene HB9

homeobox protein HB9

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08571	MNX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20296	Mnx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26804	Mnx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mnx1	NCBI	NCBI:3110

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