2. Gene
  3. Hk2 - hexokinase 2 Gene

Hk2 - hexokinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HKII

Gene ID: 15277 | Gene type: protein coding

About Hk2

Summary

Enables Hexokinase activity. Involved in negative regulation of mitochondrial membrane permeability and negative regulation of Reactive Oxygen Species metabolic process. Acts upstream of or within several processes, including carbohydrate phosphorylation; cellular response to leukemia inhibitory factor; and regulation of glucose import. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (Hexokinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hk2 Products(1)

mRNA Protein Name
NM_013820.4 NP_038848.1 hexokinase-2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables hexokinase activity IDA
IDA: Inferred from direct assay
18165236 MGI
enables hexokinase activity IMP
IMP: Inferred from mutant phenotype
10428828 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within apoptotic mitochondrial changes IGI
IGI: Inferred from genetic interaction
18350175 MGI
acts upstream of or within carbohydrate phosphorylation IMP
IMP: Inferred from mutant phenotype
10428828 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
10428828 MGI
involved in negative regulation of mitochondrial membrane permeability IMP
IMP: Inferred from mutant phenotype
22517678 MGI
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
22517678 MGI
acts upstream of or within regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
17639019 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hexokinase-2

HK II

hexokinase type II

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101563 GSK3326595 Inhibitor 99.83% Phase 2
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112780 UC2288 99.92% Unkown
HY-155008 PROTAC HK2 Degrader-1 Degrader 98.98% Unkown
HY-N0911 Rehmannioside A 99.96% Unkown
HY-N8407 Carminic acid 95.04% Unkown
HY-151432 URAT1 inhibitor 3 Inhibitor 98.02% Unkown
HY-130437 p-nitro-Pifithrin-α ≥97.0% Unkown
HY-156276 SP4e Activator 99.72% Unkown
HY-156277 SP4f Activator 99.77% Unkown
HY-156368 RIPK3-IN-4 Inhibitor / Unkown
HY-N10760 2a,3a,23-Trihydroxyurs-12,20(30)-dien-28-oic acid / Unkown
HY-RS06193 HK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06288 HOOK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07101 KCNA5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07282 KIF2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07380 KLK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16576 Hk2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23009 Hk2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hk2 NCBI NCBI:3099