Hint1 - histidine triad nucleotide binding protein 1 Gene

Mus musculus

Also known as Hint; Ipk1; PKCI-1; PRKCNH1

Gene ID: 15254 | Gene type: protein coding

About Hint1

Summary

Predicted to enable adenosine 5'-monophosphoramidase activity. Involved in positive regulation of calcium-mediated signaling and protein desumoylation. Located in nucleus. Is expressed in several structures, including brain; colon; genitourinary system; mammary gland; and spleen. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to human HINT1 (histidine triad nucleotide binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Hint1 Products(1)

mRNA	Protein	Name
NM_008248.3	NP_032274.1	adenosine 5'-monophosphoramidase HINT1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables deSUMOylase activity	IDA IDA: Inferred from direct assay	31088288	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	31088288	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	23576580	MGI
involved in protein desumoylation	IMP IMP: Inferred from mutant phenotype	31088288	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9770345	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adenosine 5'-monophosphoramidase HINT1

PKC inhibitor/ interacting protein	adenosine 5'-monophosphoramidase
desumoylating isopeptidase HINT1	protein kinase C inhibitor 1
protein kinase C-interacting protein 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-113337	Ap4A	Inducer	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113337A	Ap4A tetraammonium	Inducer	≥97.0%	Unkown
HY-138885	Tryptamine guanosine carbamate	Inhibitor	99.79%	Unkown
HY-173016	HINT1-IN-1	Modulator	/	Unkown
HY-RS06176	HINT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21594	Hint1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hint1	NCBI	NCBI:3094

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