2. Gene
  3. Hhip - Hedgehog-interacting protein Gene

Hhip - Hedgehog-interacting protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Hhip1

Gene ID: 15245 | Gene type: protein coding

About Hhip

Summary

Predicted to enable Hedgehog family protein binding activity and zinc ion binding activity. Involved in negative regulation of smoothened signaling pathway and skeletal system morphogenesis. Acts upstream of or within several processes, including epithelial tube branching involved in lung morphogenesis; neuroblast proliferation; and regulation of Fibroblast Growth Factor receptor signaling pathway. Located in cell surface. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (Hedgehog interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Hhip Products(1)

mRNA Protein Name
NM_020259.4 NP_064655.4 hedgehog-interacting protein precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10050855 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
12917290 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
15576403 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
12569124 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
10050855 MGI
involved in negative regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
15294024 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
12569124 MGI
acts upstream of or within neuroblast proliferation IGI
IGI: Inferred from genetic interaction
15576403 MGI
acts upstream of or within regulation of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12569124 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
10050855 MGI
involved in skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
10050855 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
15576403 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10050855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hedgehog-interacting protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06160 HHIP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21354 Hhip Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hhip NCBI NCBI:64399