Hes1 - hes family bHLH transcription factor 1 Gene

Mus musculus

Also known as Hry; bHLHb39

Gene ID: 15205 | Gene type: protein coding

About Hes1

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HLH domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; regulation of gliogenesis; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and nervous system development. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; foot bone; and sensory organ. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hes1 Products(2)

mRNA	Protein	Name
NM_001413568.1	NP_001400497.1	transcription factor HES-1 isoform 2
NM_008235.3	NP_032261.1	transcription factor HES-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10851137	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15870295	MGI
enables DNA-binding transcription repressor activity	IDA IDA: Inferred from direct assay	17681138	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21259317	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	10851137	MGI
enables HLH domain binding	IDA IDA: Inferred from direct assay	17681138	MGI
enables N-box binding	IDA IDA: Inferred from direct assay	10851137	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10851137	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15156153	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21259317	MGI
enables protein-folding chaperone binding	IDA IDA: Inferred from direct assay	16314515	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	18579678	MGI
acts upstream of Cajal-Retzius cell differentiation	IGI IGI: Inferred from genetic interaction	18579678	MGI
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25535395	MGI
involved in S-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	15870295	MGI
acts upstream of or within adenohypophysis development	IMP IMP: Inferred from mutant phenotype	18996108	MGI
acts upstream of amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	16038893	MGI
involved in aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	20122914	MGI
involved in artery morphogenesis	IMP IMP: Inferred from mutant phenotype	20122914	MGI
involved in ascending aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	19609448	MGI
acts upstream of or within cardiac neural crest cell development involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19609448	MGI
acts upstream of or within cell adhesion	IGI IGI: Inferred from genetic interaction	15496443	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	10952889	MGI
acts upstream of cell fate determination	IMP IMP: Inferred from mutant phenotype	11425898	MGI
acts upstream of or within cell maturation	IGI IGI: Inferred from genetic interaction	15496443	MGI
acts upstream of or within cell migration	IGI IGI: Inferred from genetic interaction	18996108	MGI
acts upstream of or within cell morphogenesis involved in neuron differentiation	IGI IGI: Inferred from genetic interaction	11500373	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16038893	MGI
acts upstream of or within cochlea development	IGI IGI: Inferred from genetic interaction	18302773	MGI
acts upstream of or within cochlea development	IMP IMP: Inferred from mutant phenotype	18302773	MGI
involved in comma-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within common bile duct development	IMP IMP: Inferred from mutant phenotype	19619492	MGI
involved in embryonic heart tube morphogenesis	IMP IMP: Inferred from mutant phenotype	19609448	MGI
acts upstream of or within establishment of epithelial cell polarity	IGI IGI: Inferred from genetic interaction	21300049	MGI
involved in glomerulus vasculature development	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within hindbrain morphogenesis	IGI IGI: Inferred from genetic interaction	11500373	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	11500373	MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	10952889	MGI
acts upstream of inner ear auditory receptor cell differentiation	IGI IGI: Inferred from genetic interaction	21300049	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IGI IGI: Inferred from genetic interaction	21300049	MGI
involved in labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	20122914	MGI
acts upstream of or within lateral inhibition	IMP IMP: Inferred from mutant phenotype	10804175	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	15578515	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	10952889	MGI
involved in metanephric nephron tubule morphogenesis	IEP IEP: Inferred from expression pattern	15465493	MGI
acts upstream of or within midbrain development	IGI IGI: Inferred from genetic interaction	11500373	MGI
acts upstream of or within midbrain-hindbrain boundary morphogenesis	IGI IGI: Inferred from genetic interaction	11500373	MGI
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10851137	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12208538	MGI
acts upstream of or within negative regulation of amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	16038893	MGI
acts upstream of or within negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	17426285	MGI
acts upstream of or within negative regulation of cell fate determination	IMP IMP: Inferred from mutant phenotype	11425898	MGI
involved in negative regulation of glial cell proliferation	IDA IDA: Inferred from direct assay	12666205	MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation	IGI IGI: Inferred from genetic interaction	21300049	MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	11023859	MGI
involved in negative regulation of inner ear receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	12208538	MGI
acts upstream of or within negative regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	10205173	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	10205173	MGI
involved in negative regulation of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	12666205	MGI
acts upstream of or within negative regulation of pancreatic A cell differentiation	IMP IMP: Inferred from mutant phenotype	10615124	MGI
acts upstream of or within negative regulation of stomach neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	18173746	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11260262	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10851137	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19050759	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15870295	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19609448	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	10804175	MGI
acts upstream of neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	10952889	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	10205173	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	10205173	MGI
involved in neuronal stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	11399758	MGI
acts upstream of or within oculomotor nerve development	IGI IGI: Inferred from genetic interaction	11500373	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19609448	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	20122914	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	19619492	MGI
acts upstream of pancreatic A cell differentiation	IMP IMP: Inferred from mutant phenotype	10615124	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	18302773	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	18302773	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	20122914	MGI
acts upstream of or within pituitary gland development	IGI IGI: Inferred from genetic interaction	17426285	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	17015435	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	18579678	MGI
involved in positive regulation of DNA binding	IDA IDA: Inferred from direct assay	15156153	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12208538	MGI
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	12208538	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	15870295	MGI
involved in positive regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	12666205	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16038893	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20122914	MGI
involved in positive regulation of mitotic cell cycle, embryonic	IMP IMP: Inferred from mutant phenotype	19609448	MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	15156153	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	11500373	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19609448	MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	15156153	MGI
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	15156153	MGI
acts upstream of or within regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	21300049	MGI
acts upstream of or within regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	15060169	MGI
acts upstream of or within regulation of neurogenesis	IGI IGI: Inferred from genetic interaction	10804175	MGI
acts upstream of or within regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	10804175	MGI
involved in regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	15156153	MGI
acts upstream of or within regulation of secondary heart field cardioblast proliferation	IMP IMP: Inferred from mutant phenotype	19609448	MGI
acts upstream of or within regulation of timing of cell differentiation	IMP IMP: Inferred from mutant phenotype	8543157	MGI
acts upstream of or within regulation of timing of neuron differentiation	IGI IGI: Inferred from genetic interaction	11500373	MGI
acts upstream of or within regulation of timing of neuron differentiation	IMP IMP: Inferred from mutant phenotype	8543157	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20628571	MGI
involved in renal interstitial fibroblast development	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: Inferred from direct assay	19124651	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	10615124	MGI
acts upstream of stomach neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	18173746	MGI
acts upstream of or within telencephalon development	IGI IGI: Inferred from genetic interaction	18579678	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	19050759	MGI
involved in thymus development	IMP IMP: Inferred from mutant phenotype	20122914	MGI
acts upstream of or within trochlear nerve development	IGI IGI: Inferred from genetic interaction	11500373	MGI
involved in ureteric bud morphogenesis	IEP IEP: Inferred from expression pattern	15821257	MGI
involved in vascular associated smooth muscle cell development	IMP IMP: Inferred from mutant phenotype	20122914	MGI
involved in ventricular septum development	IMP IMP: Inferred from mutant phenotype	20122914	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	19609448	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15645444	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	16489008	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10952889	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17681138	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor HES-1

hairy and enhancer of split 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19369	L-685458		99.48%	Unkown
HY-117113	JI051	Inhibitor	≥98.0%	Unkown
HY-107245	Segetalin B		99.51%	Unkown
HY-164410	MO-I-1100	Inhibitor	99.76%	Unkown
HY-124484	JI130	Inhibitor	99.01%	Unkown
HY-RS06134	HES1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N3393	Lethedioside A		/	Unkown
HY-RS17070	Hes1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23514	Hes1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hes1	NCBI	NCBI:3280

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