2. Gene
  3. Heph - hephaestin Gene

Heph - hephaestin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cpl; sla; mKIAA0698; C130006F04Rik

Gene ID: 15203 | Gene type: protein coding

About Heph

Summary

Predicted to enable copper ion binding activity; ferrous iron binding activity; and ferroxidase activity. Acts upstream of or within erythrocyte differentiation. Predicted to be located in basolateral plasma membrane and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Orthologous to human HEPH (hephaestin). [provided by Alliance of Genome Resources, Apr 2022]

Heph Products(4)

mRNA Protein Name
NM_001159627.1 NP_001153099.1 hephaestin isoform 1 precursor
NM_001159628.1 NP_001153100.1 hephaestin isoform 3 precursor
NM_010417.2 NP_034547.2 hephaestin isoform 1 precursor
NM_181273.4 NP_851790.1 hephaestin isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ferroxidase activity IDA
IDA: Inferred from direct assay
14751926 MGI
Biological Process GO Annotation Evidence Reference Source
involved in intestinal iron absorption IMP
IMP: Inferred from mutant phenotype
9988272 MGI
involved in multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
9988272 MGI
involved in positive regulation of iron export across plasma membrane IDA
IDA: Inferred from direct assay
30647129 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hephaestin

haphaestin

sex linked anemia

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06124 HEPH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18035 Heph Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24509 Heph Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Heph NCBI NCBI:9843
Rattus norvegicus Heph NCBI NCBI:117240