Htt - huntingtin Gene

Mus musculus

Also known as Hd; Hdh; IT15; C430023I11Rik

Gene ID: 15194 | Gene type: protein coding

About Htt

Summary

Enables diazepam binding activity. Involved in several processes, including postsynapse to nucleus signaling pathway; regulation of cAMP-dependent protein kinase activity; and regulation of protein localization to nucleus. Acts upstream of or within several processes, including carboxylic acid metabolic process; positive regulation of cilium assembly; and transport along microtubule. Located in several cellular components, including centriole; inclusion body; and perinuclear region of cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; olfactory epithelium; peripheral nervous system; retina; and testis. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (Huntingtin). [provided by Alliance of Genome Resources, Apr 2022]

Htt Products(1)

mRNA	Protein	Name
NM_010414.3	NP_034544.1	huntingtin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables diazepam binding	IMP IMP: Inferred from mutant phenotype	10082833	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9599014	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	18595722	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17715336	MGI
acts upstream of or within anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	16109169	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	16109169	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	17284197	MGI
acts upstream of or within axo-dendritic transport	IMP IMP: Inferred from mutant phenotype	15340079	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	16978870	MGI
acts upstream of or within cellular senescence	IMP IMP: Inferred from mutant phenotype	16403806	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	9398841	MGI
acts upstream of or within citrulline metabolic process	IMP IMP: Inferred from mutant phenotype	17213233	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	11062468	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	9398841	MGI
acts upstream of or within endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	16256944	MGI
acts upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	11092755	MGI
acts upstream of or within endosomal transport	IMP IMP: Inferred from mutant phenotype	11092755	MGI
acts upstream of or within gastrulation	IMP IMP: Inferred from mutant phenotype	7550343	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	30391555	MGI
acts upstream of or within grooming behavior	IMP IMP: Inferred from mutant phenotype	10778856	MGI
acts upstream of or within hormone metabolic process	IMP IMP: Inferred from mutant phenotype	10078572	MGI
acts upstream of or within insulin secretion	IMP IMP: Inferred from mutant phenotype	10078572	MGI
acts upstream of or within lactate biosynthetic process from pyruvate	IMP IMP: Inferred from mutant phenotype	17708681	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	16624677	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	16403806	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	7774020	MGI
acts upstream of or within mitochondrial transport	IMP IMP: Inferred from mutant phenotype	15340079	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	11092755	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	11092755	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15242649	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	7550343	MGI
acts upstream of or within neural plate formation	IMP IMP: Inferred from mutant phenotype	7774020	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	11062468	MGI
NOT acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	10037472	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	7774020	MGI
acts upstream of or within olfactory lobe development	IMP IMP: Inferred from mutant phenotype	12926013	MGI
acts upstream of or within paraxial mesoderm formation	IMP IMP: Inferred from mutant phenotype	16109169	MGI
acts upstream of or within peptide hormone secretion	IMP IMP: Inferred from mutant phenotype	10078572	MGI
acts upstream of or within positive regulation of motile cilium assembly	IMP IMP: Inferred from mutant phenotype	21985783	MGI
acts upstream of or within positive regulation of non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	21985783	MGI
involved in postsynapse to nucleus signaling pathway	IDA IDA: Inferred from direct assay	20739295	MGI
involved in postsynapse to nucleus signaling pathway	IEP IEP: Inferred from expression pattern	20739295	MGI
involved in postsynapse to nucleus signaling pathway	IMP IMP: Inferred from mutant phenotype	20739295	MGI
acts upstream of or within protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	21985783	MGI
acts upstream of or within protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	11092755	MGI
acts upstream of or within quinolinate biosynthetic process	IMP IMP: Inferred from mutant phenotype	16697652	MGI
involved in regulation of cAMP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	21768291	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21768291	MGI
involved in regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21768291	MGI
involved in regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	21768291	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	10196373	MGI
acts upstream of or within response to calcium ion	IMP IMP: Inferred from mutant phenotype	15935052	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	10196365	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	11062468	MGI
acts upstream of or within striatum development	IMP IMP: Inferred from mutant phenotype	11030759	MGI
acts upstream of or within urea cycle	IMP IMP: Inferred from mutant phenotype	17213233	MGI
acts upstream of or within vesicle transport along microtubule	IDA IDA: Inferred from direct assay	15242649	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	7774020	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	8757264	MGI
located in centriole	IDA IDA: Inferred from direct assay	21985783	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	7647777	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15242649	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	25738228	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20739295	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	20739295	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20739295	MGI
located in inclusion body	IDA IDA: Inferred from direct assay	15615787	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	25738228	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

huntingtin

HD protein homolog	Huntington disease gene homolog
huntington disease protein homolog

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132579	Tominersen		94.13%	Phase 3
HY-132593	Rovanersen		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16009	Buntanetap		99.71%	Unkown
HY-156650	Votoplam	Modulator	99.51%	Unkown
HY-132579A	Tominersen sodium		97.36%	Unkown
HY-136780	SEN177	Inhibitor	98.76%	Unkown
HY-156103	mHTT-IN-2	Inhibitor	99.35%	Unkown
HY-150236	FITC-labeled Tominersen sodium	Inhibitor	95.72%	Unkown
HY-132593A	Rovanersen sodium		95.58%	Unkown
HY-16009B	Buntanetap L-Tartrate		98.93%	Unkown
HY-143792	HTT-D3	Inhibitor	/	Unkown
HY-10542A	(Z)-GW 5074	Inhibitor	/	Unkown
HY-P10822	ED11	Inhibitor	/	Unkown
HY-RS06490	HTT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13311	SLC6A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13312	Slc6a4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W792458	MADAM	Ligand	/	Unkown
HY-RS18021	Htt Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24494	Htt Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htt	NCBI	NCBI:3064

Name
Email *

	Sorry, but the email address you supplied was invalid.