2. Gene
  3. Hcrt - hypocretin Gene

Hcrt - hypocretin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PPOX

Gene ID: 15171 | Gene type: protein coding

About Hcrt

Summary

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015]

Hcrt Products(1)

mRNA Protein Name
NM_010410.2 NP_034540.1 hypocretin neuropeptide precursor precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
23700511 MGI
Cellular Component GO Annotation Evidence Reference Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11748295 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hypocretin neuropeptide precursor

hypocretin neuropeptide

orexin A

orexin B

prepro-orexin

preprohypocretin

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-128850 N-Acetyl-D-mannosamine ≥98.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06050 HCRT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18943 Hcrt Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25433 Hcrt Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcrt NCBI NCBI:3060