Hcls1 - hematopoietic cell specific Lyn substrate 1 Gene

Mus musculus

Also known as HS1

Gene ID: 15163 | Gene type: protein coding

About Hcls1

Summary

Enables SH3 domain binding activity. Involved in several processes, including positive regulation of myeloid leukocyte differentiation; positive regulation of tyrosine phosphorylation of STAT protein; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

Hcls1 Products(1)

mRNA	Protein	Name
NM_008225.2	NP_032251.2	hematopoietic lineage cell-specific protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IDA IDA: Inferred from direct assay	9126384	MGI
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	19064729	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7506729	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	19064729	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10713104	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23001182	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10713104	MGI
involved in positive regulation of granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	23001182	MGI
involved in positive regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	23001182	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23001182	MGI
involved in response to hormone	IDA IDA: Inferred from direct assay	10713104	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10713104	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10713104	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hematopoietic lineage cell-specific protein

hematopoietic cell-specific LYN substrate 1

lckBP1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06045	HCLS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17702	Hcls1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24166	Hcls1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hcls1	NCBI	NCBI:3059

Name
Email *

	Sorry, but the email address you supplied was invalid.