Gstp1 - glutathione S-transferase, pi 1 Gene

Mus musculus

Also known as GstpiB

Gene ID: 14870 | Gene type: protein coding

About Gstp1

Summary

Enables JUN kinase binding activity; glutathione transferase activity; and kinase regulator activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of intracellular signal transduction; and negative regulation of macromolecule metabolic process. Acts upstream of or within glutathione metabolic process. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); carcinoma (multiple); hematologic Cancer (multiple); reproductive organ Cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (Glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Apr 2022]

Gstp1 Products(1)

mRNA	Protein	Name
NM_013541.1	NP_038569.1	glutathione S-transferase P 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables JUN kinase binding	IPI IPI: Inferred from physical interaction	11279197	MGI
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	7982937	MGI
enables kinase regulator activity	IMP IMP: Inferred from mutant phenotype	12646564	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	16023107	MGI
involved in common myeloid progenitor cell proliferation	IMP IMP: Inferred from mutant phenotype	11408560	MGI
acts upstream of or within glutathione metabolic process	IDA IDA: Inferred from direct assay	7982937	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	16023107	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	16023107	MGI
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	11408560	MGI
involved in negative regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	18962899	MGI
involved in negative regulation of leukocyte proliferation	IMP IMP: Inferred from mutant phenotype	11408560	MGI
involved in negative regulation of monocyte chemotactic protein-1 production	IDA IDA: Inferred from direct assay	18962899	MGI
involved in negative regulation of nitric-oxide synthase biosynthetic process	IDA IDA: Inferred from direct assay	16023107	MGI
involved in negative regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	16023107	MGI
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	16023107	MGI
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	11408560	MGI
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	10945608	MGI
involved in regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	10945608	MGI
involved in response to reactive oxygen species	IDA IDA: Inferred from direct assay	10945608	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	15100242	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	11279197	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutathione S-transferase P 1

GST YF-YF	GST class-pi
GST-piB	Gst p-1
gst P1	preadipocyte growth factor

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13634A	Ezatiostat		99.82%	Phase 2
HY-13634	Ezatiostat hydrochloride		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135318	NBDHEX		98.56%	Unkown
HY-115673	LAS17	Inhibitor	97.46%	Unkown
HY-13634B	TLK117	Inhibitor	99.89%	Unkown
HY-112534	GSTO-IN-2	Inhibitor	98.0%	Unkown
HY-145413	BRD2889	Inhibitor	/	Unkown
HY-132913	Cyclopropenone probe 1		/	Unkown
HY-160455	GSTP1-1 inhibitor 1		/	Unkown
HY-169058	GSTP1-1 inhibitor 2	Inhibitor	/	Unkown
HY-178372	GSTO1-IN-4	Inhibitor	/	Unkown
HY-RS05886	GSTP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W615446	GSTO1-IN-3	Inhibitor	/	Unkown
HY-16123	Canfosfamide hydrochloride	Chemical	/	Unkown
HY-N11778	Bequinostatin C		/	Unkown
HY-RS16643	Gstp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23077	Gstp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gstp1	NCBI	NCBI:2950
Rattus norvegicus	Gstp1	NCBI	NCBI:24426

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