2. Gene
  3. Grik1 - glutamate receptor, ionotropic, kainate 1 Gene

Grik1 - glutamate receptor, ionotropic, kainate 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GluK1; GluK5; Glur5; Glur-5; D16Ium24; D16Ium24e; Glurbeta1; A830007B11Rik

Gene ID: 14805 | Gene type: protein coding

About Grik1

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

Grik1 Products(11)

mRNA Protein Name
NM_001346964.2 NP_001333893.2 glutamate receptor ionotropic, kainate 1 isoform c
NM_001405028.1 NP_001391957.1 glutamate receptor ionotropic, kainate 1 isoform d
NM_001405029.1 NP_001391958.1 glutamate receptor ionotropic, kainate 1 isoform e
NM_001405030.1 NP_001391959.1 glutamate receptor ionotropic, kainate 1 isoform f
NM_001405031.1 NP_001391960.1 glutamate receptor ionotropic, kainate 1 isoform g
NM_001405032.1 NP_001391961.1 glutamate receptor ionotropic, kainate 1 isoform h
NM_001405033.1 NP_001391962.1 glutamate receptor ionotropic, kainate 1 isoform i
NM_001405034.1 NP_001391963.1 glutamate receptor ionotropic, kainate 1 isoform j
NM_001405035.1 NP_001391964.1 glutamate receptor ionotropic, kainate 1 isoform k precursor
NM_010348.4 NP_034478.2 glutamate receptor ionotropic, kainate 1 isoform b precursor
NM_146072.5 NP_666184.3 glutamate receptor ionotropic, kainate 1 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-glutamate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
14715943 MGI
enables kainate selective glutamate receptor activity IDA
IDA: Inferred from direct assay
15483117 MGI
enables kainate selective glutamate receptor activity IGI
IGI: Inferred from genetic interaction
11985817 MGI
enables kainate selective glutamate receptor activity IMP
IMP: Inferred from mutant phenotype
12223554 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17174564 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
17245443 MGI
acts upstream of or within behavioral response to pain IMP
IMP: Inferred from mutant phenotype
15673679 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
17245443 MGI
acts upstream of or within excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
11985817 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
11069933 MGI
acts upstream of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
17245443 MGI
acts upstream of or within inhibitory postsynaptic potential IGI
IGI: Inferred from genetic interaction
11144357 MGI
acts upstream of or within inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
12223554 MGI
acts upstream of or within membrane depolarization IMP
IMP: Inferred from mutant phenotype
17245443 MGI
acts upstream of or within negative regulation of synaptic transmission, glutamatergic IGI
IGI: Inferred from genetic interaction
11985817 MGI
acts upstream of or within positive regulation of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
17245443 MGI
acts upstream of or within positive regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
17245443 MGI
acts upstream of or within presynaptic modulation of chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
11985817 MGI
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
17174564 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
10516295 MGI
acts upstream of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
17245443 MGI
acts upstream of or within synaptic transmission, glutamatergic IGI
IGI: Inferred from genetic interaction
15928066 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
15509753 MGI
Cellular Component GO Annotation Evidence Reference Source
located in dendrite IDA
IDA: Inferred from direct assay
17174564 MGI
part of kainate selective glutamate receptor complex IPI
IPI: Inferred from physical interaction
17174564 MGI
located in membrane IDA
IDA: Inferred from direct assay
15014126 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
21734292 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
11985817 MGI
located in synapse IDA
IDA: Inferred from direct assay
21734292 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor ionotropic, kainate 1

glutamate receptor subunit 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05798 GRIK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22540 Grik1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grik1 NCBI NCBI:2897