2. Gene
  3. Gnmt - glycine N-methyltransferase Gene

Gnmt - glycine N-methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 14711 | Gene type: protein coding

About Gnmt

Summary

Enables glycine N-methyltransferase activity and glycine binding activity. Involved in S-adenosylmethionine metabolic process and protein homotetramerization. Acts upstream of or within several processes, including glycogen metabolic process; one-carbon metabolic process; and regulation of gluconeogenesis. Predicted to be located in nucleus. Predicted to be part of methyltransferase complex. Predicted to be active in cytosol. Is expressed in several structures, including integumental system; limb; nose; pancreas tip epithelium; and skeleton. Used to study glycine N-methyltransferase deficiency and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Gnmt Products(3)

mRNA Protein Name
NM_001364890.1 NP_001351819.1 glycine N-methyltransferase isoform 2
NM_001413152.1 NP_001400081.1 glycine N-methyltransferase isoform 3
NM_010321.1 NP_034451.1 glycine N-methyltransferase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables glycine N-methyltransferase activity IDA
IDA: Inferred from direct assay
15340920 MGI
enables glycine binding IDA
IDA: Inferred from direct assay
15340920 MGI
Biological Process GO Annotation Evidence Reference Source
involved in S-adenosylmethionine metabolic process IDA
IDA: Inferred from direct assay
15340920 MGI
acts upstream of or within glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
17937387 MGI
acts upstream of or within methionine metabolic process IMP
IMP: Inferred from mutant phenotype
17937387 MGI
acts upstream of or within one-carbon metabolic process IMP
IMP: Inferred from mutant phenotype
17937387 MGI
involved in protein homotetramerization IPI
IPI: Inferred from physical interaction
15340920 MGI
acts upstream of or within regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
17937387 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycine N-methyltransferase

glycine N methyl transferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05569 GNMT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17639 Gnmt Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24099 Gnmt Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnmt NCBI NCBI:27232