2. Gene
  3. Gnb1 - guanine nucleotide binding protein (G protein), beta 1 Gene

Gnb1 - guanine nucleotide binding protein (G protein), beta 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Hg2a; Gnb-1

Gene ID: 14688 | Gene type: protein coding

About Gnb1

Summary

Predicted to enable several functions, including GTPase binding activity; alkylglycerophosphoethanolamine phosphodiesterase activity; and spectrin binding activity. Acts upstream of or within several processes, including Phospholipase C-activating G protein-coupled receptor signaling pathway; retina development in camera-type eye; and sensory perception of taste. Located in photoreceptor outer segment. Part of heterotrimeric G-protein complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant non-syndromic intellectual disability 42; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Gnb1 Products(3)

mRNA Protein Name
NM_001160016.1 NP_001153488.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
NM_001160017.1 NP_001153489.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
NM_008142.4 NP_032168.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
14712229 MGI
acts upstream of or within cell population proliferation IDA
IDA: Inferred from direct assay
14712229 MGI
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
10570481 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within sensory perception of taste IDA
IDA: Inferred from direct assay
10570481 MGI
Cellular Component GO Annotation Evidence Reference Source
part of heterotrimeric G-protein complex IPI
IPI: Inferred from physical interaction
10570481 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
18367617 MGI
is active in synapse EXP
EXP: Inferred from Experiment
34932372 MGI
is active in synapse IDA
IDA: Inferred from direct assay
34932372 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

guanine nucleotide binding protein, beta 1

heterotrimeric guanine nucleotide-binding protein 2a

transducin beta chain 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05545 GNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05546 GNB1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20745 Gnb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27257 Gnb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnb1 NCBI NCBI:2782