Gnaq - guanine nucleotide binding protein, alpha q polypeptide Gene

Mus musculus

Also known as Gq; GqI; Dsk1; Dsk10; Galphaq; 1110005L02Rik; 6230401I02Rik

Gene ID: 14682 | Gene type: protein coding

About Gnaq

Summary

Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activator activity; and alkylglycerophosphoethanolamine phosphodiesterase activity. Involved in several processes, including cranial skeletal system development; Endothelin Receptor signaling pathway; and multicellular organism aging. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; maternal behavior; and neuron development. Located in cell body; dendrite; and membrane. Is expressed in several structures, including central nervous system; gonad; heart; intestine smooth muscle circular layer; and retina. Used to study congestive heart failure and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; congestive heart failure; and familial multiple nevi flammei. Orthologous to human GNAQ (G protein subunit alpha q). [provided by Alliance of Genome Resources, Apr 2022]

Gnaq Products(1)

mRNA	Protein	Name
NM_008139.6	NP_032165.3	guanine nucleotide-binding protein G(q) subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein activity	IDA IDA: Inferred from direct assay	20966218	MGI
enables G protein activity	IMP IMP: Inferred from mutant phenotype	26075576	MGI
enables enzyme regulator activity	IDA IDA: Inferred from direct assay	37991948	MGI
enables enzyme regulator activity	IMP IMP: Inferred from mutant phenotype	26075576	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9016340	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9687499	MGI
acts upstream of or within action potential	IMP IMP: Inferred from mutant phenotype	10818132	MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10481072	MGI
involved in cranial skeletal system development	IGI IGI: Inferred from genetic interaction	18199583	MGI
acts upstream of or within developmental pigmentation	IMP IMP: Inferred from mutant phenotype	15322542	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	12077299	MGI
involved in endothelin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18199583	MGI
acts upstream of or within forebrain neuron development	IMP IMP: Inferred from mutant phenotype	15340067	MGI
acts upstream of or within glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11438569	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	9687499	MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in ligand-gated ion channel signaling pathway	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in ligand-gated ion channel signaling pathway	IMP IMP: Inferred from mutant phenotype	26075576	MGI
acts upstream of or within maternal behavior	IMP IMP: Inferred from mutant phenotype	15340067	MGI
acts upstream of or within neuron remodeling	IMP IMP: Inferred from mutant phenotype	9391157	MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	20966218	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26075576	MGI
acts upstream of or within phospholipase C-activating dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	17194762	MGI
involved in positive regulation of insulin secretion	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	26075576	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	15340067	MGI
involved in regulation of blood pressure	IGI IGI: Inferred from genetic interaction	26531127	MGI
acts upstream of or within regulation of melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	15322542	MGI
involved in regulation of platelet activation	IMP IMP: Inferred from mutant phenotype	9296496	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	9687499	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body	IDA IDA: Inferred from direct assay	11685543	MGI
located in dendrite	IDA IDA: Inferred from direct assay	11685543	MGI
located in membrane	IDA IDA: Inferred from direct assay	9016340	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	9765251	MGI
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	27276689	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(q) subunit alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05539	GNAQ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22188	Gnaq Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnaq	NCBI	NCBI:2776

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