Glra1 - glycine receptor, alpha 1 subunit Gene

Mus musculus

Also known as ot; spd; nmf11; spasmodic; oscillator

Gene ID: 14654 | Gene type: protein coding

About Glra1

Summary

Enables extracellularly glycine-gated Chloride Channel activity; glycine binding activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in glycinergic synaptic transmission; inhibitory postsynaptic potential; and response to alcohol. Acts upstream of or within several processes, including adult walking behavior; regulation of respiratory gaseous exchange by nervous system process; and righting reflex. Located in several cellular components, including external side of plasma membrane; glycinergic synapse; and inhibitory synapse. Is expressed in brain; brainstem; and spinal cord. Used to study hyperekplexia and hyperekplexia 1. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Glra1 Products(2)

mRNA	Protein	Name
NM_001290821.1	NP_001277750.1	glycine receptor subunit alpha-1 isoform 1 precursor
NM_020492.4	NP_065238.2	glycine receptor subunit alpha-1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables extracellularly glycine-gated chloride channel activity	IDA IDA: Inferred from direct assay	8062927	MGI
enables extracellularly glycine-gated chloride channel activity	IMP IMP: Inferred from mutant phenotype	16672662	MGI
enables glycine binding	IDA IDA: Inferred from direct assay	7874121	MGI
enables glycine binding	IMP IMP: Inferred from mutant phenotype	8062927	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	28724750	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	28724750	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within acrosome reaction	IMP IMP: Inferred from mutant phenotype	11076688	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	17114051	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12837931	MGI
acts upstream of or within inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17114051	MGI
involved in inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	24801766	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	9087981	MGI
acts upstream of or within neuromuscular process controlling posture	IMP IMP: Inferred from mutant phenotype	17114051	MGI
acts upstream of or within neuronal action potential	IMP IMP: Inferred from mutant phenotype	11742725	MGI
acts upstream of or within regulation of membrane potential	IDA IDA: Inferred from direct assay	8062927	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	16672662	MGI
acts upstream of or within regulation of respiratory gaseous exchange	IMP IMP: Inferred from mutant phenotype	11742725	MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process	IMP IMP: Inferred from mutant phenotype	16800867	MGI
involved in response to alcohol	IMP IMP: Inferred from mutant phenotype	24801766	MGI
acts upstream of or within righting reflex	IMP IMP: Inferred from mutant phenotype	17114051	MGI
acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	8406478	MGI
acts upstream of or within synaptic transmission, glycinergic	IMP IMP: Inferred from mutant phenotype	16672662	MGI
involved in synaptic transmission, glycinergic	IMP IMP: Inferred from mutant phenotype	24801766	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	17114051	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17145751	MGI
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	28724750	MGI
is active in glycinergic synapse	IMP IMP: Inferred from mutant phenotype	28724750	MGI
located in inhibitory synapse	IDA IDA: Inferred from direct assay	9812897	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	17145751	MGI
located in membrane	IDA IDA: Inferred from direct assay	1371219	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	24801766	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	24801766	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	16964444	MGI
located in synapse	IDA IDA: Inferred from direct assay	24801766	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glycine receptor subunit alpha-1

glycine receptor 48 kDa subunit

glycine receptor strychnine-binding subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05492	GLRA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22528	Glra1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29048	Glra1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Glra1	NCBI	NCBI:2741

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