Gli3 - GLI-Kruppel family member GLI3 Gene

Mus musculus

Also known as Xt; Bph; Pdn; add; GLI3FL; GLI3-190

Gene ID: 14634 | Gene type: protein coding

About Gli3

Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative thymic T cell selection; regulation of alpha-beta T cell differentiation; and thymocyte apoptotic process. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of cell differentiation. Located in axoneme and nuclear speck. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Greig cephalopolysyndactyly syndrome and Pallister-Hall syndrome. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (Gli family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Gli3 Products(1)

mRNA	Protein	Name
NM_008130.3	NP_032156.2	transcriptional activator GLI3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11053430	MGI
enables chromatin binding	IGI IGI: Inferred from genetic interaction	16396903	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10920228	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16611981	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	15855276	MGI
involved in T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	15855276	MGI
acts upstream of or within alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	15855276	MGI
acts upstream of or within anatomical structure development	IGI IGI: Inferred from genetic interaction	11485934	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IGI IGI: Inferred from genetic interaction	9731531	MGI
acts upstream of or within anterior semicircular canal development	IMP IMP: Inferred from mutant phenotype	17395647	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	22841643	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15315762	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	19048639	MGI
acts upstream of or within artery development	IGI IGI: Inferred from genetic interaction	16968815	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15065125	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	8026071	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	16396903	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	16247775	MGI
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	18582859	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	8387379	MGI
acts upstream of or within cell differentiation involved in kidney development	IGI IGI: Inferred from genetic interaction	19809516	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16396903	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16396903	MGI
acts upstream of or within central nervous system development	IGI IGI: Inferred from genetic interaction	12435628	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	12435629	MGI
acts upstream of or within cerebral cortex radial glia-guided migration	IMP IMP: Inferred from mutant phenotype	9232833	MGI
acts upstream of chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	16284117	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	9268579	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	12435629	MGI
acts upstream of or within embryonic digestive tract development	IMP IMP: Inferred from mutant phenotype	10693670	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	16247775	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	9268572	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	16284117	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	8387379	MGI
acts upstream of or within embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	8387379	MGI
acts upstream of or within embryonic neurocranium morphogenesis	IMP IMP: Inferred from mutant phenotype	27395007	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	15728667	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	16168404	MGI
acts upstream of or within forebrain dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	10625551	MGI
acts upstream of or within forebrain radial glial cell differentiation	IMP IMP: Inferred from mutant phenotype	9232833	MGI
acts upstream of or within frontal suture morphogenesis	IMP IMP: Inferred from mutant phenotype	20570969	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	23201751	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	11172440	MGI
acts upstream of or within hindgut morphogenesis	IGI IGI: Inferred from genetic interaction	11485934	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	22235033	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16254602	MGI
acts upstream of or within inner ear development	IGI IGI: Inferred from genetic interaction	17395647	MGI
acts upstream of or within kidney development	IGI IGI: Inferred from genetic interaction	11172440	MGI
acts upstream of or within lambdoid suture morphogenesis	IMP IMP: Inferred from mutant phenotype	20570969	MGI
acts upstream of or within larynx morphogenesis	IMP IMP: Inferred from mutant phenotype	28177282	MGI
acts upstream of or within lateral ganglionic eminence cell proliferation	IMP IMP: Inferred from mutant phenotype	20943929	MGI
acts upstream of or within lateral semicircular canal development	IMP IMP: Inferred from mutant phenotype	17395647	MGI
acts upstream of or within layer formation in cerebral cortex	IMP IMP: Inferred from mutant phenotype	21525285	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	17400206	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	15136151	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	9268579	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	16914490	MGI
acts upstream of or within mammary gland specification	IGI IGI: Inferred from genetic interaction	16720875	MGI
acts upstream of or within melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	18397875	MGI
acts upstream of or within metanephros development	IGI IGI: Inferred from genetic interaction	16396903	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12435627	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17400206	MGI
involved in negative regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	19667090	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19048639	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	16396903	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16396903	MGI
acts upstream of or within negative regulation of chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	16284117	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	19048639	MGI
involved in negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19667090	MGI
acts upstream of or within negative regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	20570969	MGI
acts upstream of or within negative regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20570969	MGI
involved in negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	19667090	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	8387379	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	20943929	MGI
acts upstream of or within neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	20943929	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	19048639	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	16168404	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	9655803	MGI
acts upstream of or within oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	15880651	MGI
acts upstream of or within optic nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	16342201	MGI
acts upstream of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	20570969	MGI
acts upstream of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20570969	MGI
acts upstream of or within pallium development	IMP IMP: Inferred from mutant phenotype	10409502	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	14602680	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17328886	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11053430	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17400206	MGI
involved in positive regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	15855276	MGI
acts upstream of or within positive regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17328886	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	20943929	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	20570969	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20570969	MGI
acts upstream of or within positive regulation of protein import into nucleus	IGI IGI: Inferred from genetic interaction	17043310	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19667090	MGI
acts upstream of protein import into nucleus	IGI IGI: Inferred from genetic interaction	17043310	MGI
acts upstream of or within protein processing	IDA IDA: Inferred from direct assay	19036983	MGI
acts upstream of or within proximal/distal pattern formation	IGI IGI: Inferred from genetic interaction	16342201	MGI
acts upstream of or within proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	16342201	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9152009	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	8026071	MGI
acts upstream of or within regulation of bone development	IMP IMP: Inferred from mutant phenotype	22841643	MGI
acts upstream of or within regulation of cell differentiation	IGI IGI: Inferred from genetic interaction	16284117	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	17191253	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	18799682	MGI
acts upstream of or within regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	28817564	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	18816854	MGI
acts upstream of or within sagittal suture morphogenesis	IMP IMP: Inferred from mutant phenotype	20570969	MGI
acts upstream of or within smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	12435628	MGI
involved in smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	22234993	MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IGI IGI: Inferred from genetic interaction	17395647	MGI
acts upstream of or within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	IGI IGI: Inferred from genetic interaction	15215207	MGI
acts upstream of or within smoothened signaling pathway involved in ventral spinal cord interneuron specification	IGI IGI: Inferred from genetic interaction	15215207	MGI
acts upstream of or within spinal cord dorsal/ventral patterning	IGI IGI: Inferred from genetic interaction	15215207	MGI
acts upstream of or within spinal cord motor neuron differentiation	IGI IGI: Inferred from genetic interaction	21552265	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	20570969	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20570969	MGI
acts upstream of or within subpallium development	IMP IMP: Inferred from mutant phenotype	20943929	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	10625551	MGI
involved in thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	19667090	MGI
acts upstream of or within tongue development	IMP IMP: Inferred from mutant phenotype	18816854	MGI
acts upstream of or within tube development	IGI IGI: Inferred from genetic interaction	9731531	MGI
acts upstream of or within vocalization behavior	IMP IMP: Inferred from mutant phenotype	28177282	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axoneme	IDA IDA: Inferred from direct assay	21209331	MGI
is active in cilium	IDA IDA: Inferred from direct assay	27046536	MGI
located in cilium	IDA IDA: Inferred from direct assay	19684112	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12435627	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	19684112	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12435627	MGI
part of transcription repressor complex	IDA IDA: Inferred from direct assay	12435627	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcriptional activator GLI3

GLI3 form of 190 kDa	GLI3 full length protein
anterior digit pattern deformity	brachyphalangy
extra toes	polydactyly Nagoya
zinc finger protein GLI3

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05476	GLI3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05482	GLIS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21349	Gli3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27868	Gli3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gli3	NCBI	NCBI:2737

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