Gli2 - GLI-Kruppel family member GLI2 Gene

Mus musculus

Gene ID: 14633 | Gene type: protein coding

About Gli2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of smoothened signaling pathway. Located in several cellular components, including axoneme; ciliary tip; and nuclear speck. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Orthologous to human GLI2 (Gli family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Gli2 Products(1)

mRNA	Protein	Name
NM_001081125.1	NP_001074594.1	zinc finger protein GLI2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16880529	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16880529	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15614767	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	23201751	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16396903	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	25808752	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11238441	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16611981	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19124651	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anatomical structure development	IGI IGI: Inferred from genetic interaction	11485934	MGI
acts upstream of or within anatomical structure development	IMP IMP: Inferred from mutant phenotype	11485934	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IGI IGI: Inferred from genetic interaction	9731531	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	22841643	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	10409510	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	9731531	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	9636069	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	15496441	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9731531	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19103752	MGI
acts upstream of or within cerebellar cortex morphogenesis	IGI IGI: Inferred from genetic interaction	16571625	MGI
acts upstream of or within cerebellar cortex morphogenesis	IMP IMP: Inferred from mutant phenotype	16571625	MGI
acts upstream of or within chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	23333501	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	17395647	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	16571630	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IDA IDA: Inferred from direct assay	9247260	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	18590716	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	16342201	MGI
acts upstream of or within embryonic digestive tract development	IMP IMP: Inferred from mutant phenotype	10693670	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	19056373	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	16054035	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	9731531	MGI
acts upstream of or within floor plate formation	IMP IMP: Inferred from mutant phenotype	9636069	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	23201751	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	29659575	MGI
acts upstream of or within head development	IMP IMP: Inferred from mutant phenotype	19056373	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	11172440	MGI
acts upstream of or within hindbrain development	IGI IGI: Inferred from genetic interaction	15496441	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	8575294	MGI
acts upstream of or within hindgut morphogenesis	IGI IGI: Inferred from genetic interaction	11485934	MGI
acts upstream of or within hindgut morphogenesis	IMP IMP: Inferred from mutant phenotype	11485934	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	19056373	MGI
acts upstream of or within kidney development	IGI IGI: Inferred from genetic interaction	11172440	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	10725236	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	9731531	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	11783999	MGI
acts upstream of or within mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	11783999	MGI
acts upstream of or within morphogenesis of an epithelium	IMP IMP: Inferred from mutant phenotype	16707121	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19056373	MGI
acts upstream of or within negative regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17328886	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	28778798	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16611981	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	19056373	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	16267219	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	16950124	MGI
acts upstream of or within notochord regression	IGI IGI: Inferred from genetic interaction	10725236	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	9655803	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	9655803	MGI
acts upstream of or within osteoblast development	IDA IDA: Inferred from direct assay	16880529	MGI
acts upstream of or within osteoblast development	IMP IMP: Inferred from mutant phenotype	16880529	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	22771375	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	14602680	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	8575294	MGI
acts upstream of or within pituitary gland development	IGI IGI: Inferred from genetic interaction	10725236	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15614767	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16254602	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18590716	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17035233	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	15496441	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15496441	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	16054035	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	9731531	MGI
acts upstream of or within positive regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	16950124	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	9731531	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16880529	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16880529	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16880529	MGI
acts upstream of or within prostatic bud formation	IMP IMP: Inferred from mutant phenotype	16707121	MGI
acts upstream of or within proximal/distal pattern formation	IGI IGI: Inferred from genetic interaction	16342201	MGI
acts upstream of or within regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	28817564	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	9006072	MGI
acts upstream of or within smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	16571625	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	16571625	MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IGI IGI: Inferred from genetic interaction	17395647	MGI
acts upstream of or within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	IGI IGI: Inferred from genetic interaction	15215207	MGI
acts upstream of or within smoothened signaling pathway involved in ventral spinal cord interneuron specification	IGI IGI: Inferred from genetic interaction	15215207	MGI
acts upstream of or within spinal cord dorsal/ventral patterning	IGI IGI: Inferred from genetic interaction	15215207	MGI
acts upstream of or within spinal cord dorsal/ventral patterning	IMP IMP: Inferred from mutant phenotype	11748151	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	21552265	MGI
acts upstream of or within spinal cord ventral commissure morphogenesis	IMP IMP: Inferred from mutant phenotype	10409510	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	9731531	MGI
acts upstream of or within tube development	IGI IGI: Inferred from genetic interaction	9731531	MGI
acts upstream of or within ventral midline development	IGI IGI: Inferred from genetic interaction	10725236	MGI
acts upstream of or within ventral midline development	IMP IMP: Inferred from mutant phenotype	10725236	MGI
acts upstream of or within ventral spinal cord development	IMP IMP: Inferred from mutant phenotype	11748151	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axoneme	IDA IDA: Inferred from direct assay	21209331	MGI
located in ciliary tip	IDA IDA: Inferred from direct assay	21653639	MGI
located in cilium	IDA IDA: Inferred from direct assay	16254602	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19286674	MGI
located in cytoplasm	IGI IGI: Inferred from genetic interaction	16316410	MGI
located in membrane	IDA IDA: Inferred from direct assay	19286674	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	18590716	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	19684112	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11238441	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger protein GLI2

Tax helper protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13901	GANT 61		99.80%	Unkown
HY-RS05475	GLI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-137567	Prostaglandin E1 ethanolamide	Activator	/	Unkown
HY-RS05481	GLIS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20743	Gli2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21582	Glis2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27255	Gli2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28100	Glis2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gli2	NCBI	NCBI:2736

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